DDT, other banned pesticides found in Detroit-area black women
https://www.eurekalert.org/pub_releases/...050620.php
RELEASE: Over half of a cohort of 23-35-year-old black women from Detroit had detectable levels of organochlorine pesticides in their blood, possibly from tobacco, alcohol, and water.
A new Boston University School of Public Health (BUSPH) study published in the journal Environmental Research finds detectable levels of DDE (what DDT becomes when metabolized in the body) and other banned organochlorine pesticides (OCPs) in the blood of over 60 percent of a cohort of black women of reproductive age in the Detroit area, with higher levels in women who smoked cigarettes daily, drank more alcohol, and drank more water.
Dichlorodiphenyltrichloroethane (DDT) and other OCPs were banned decades ago. But they can dissolve into a person's body fat, and remain there for years, causing hormonal and metabolic issues, and even brain development issues from in-utero exposure.
"If cigarettes, alcohol, and drinking water are in fact exposing black women to pesticides, this matters!" says study lead author Dr. Olivia Orta, a postdoctoral research associate in the Department of Epidemiology at BUSPH. "The sources that we identified as potential OCP correlates should be tested for pesticide contamination," she says, "especially drinking water."
However, Orta cautions that the study was not able to distinguish between bottled and tap water, or test participants' tap water for these chemicals, so "we do not want to suggest that black women in Detroit reduce their water consumption in response to our study findings," she says. Instead, the study points to the importance of water monitoring--which has been notoriously inequitable, as seen in nearby Flint--and the need to test for OCPs in tap and bottled water as well as in alcohol and tobacco, she says.
Orta and colleagues used data from the Study of Environment, Lifestyle, and Fibroids (SELF), a prospective cohort study of reproductive-age black women recruited from the Detroit metropolitan area from 2010 to 2012. For the current study, the researchers analyzed blood samples from 742 fibroid-free participants, given when they entered the study, and their responses to questionnaires about health histories, demographics, behaviors, and other factors.
The researchers found detectable levels of four OCPs--dichlorodiphenyltrichloroethane (DDE), hexachlorobenzene (HCB), oxychlordane, and trans-nonachlor--in over 60 percent of the participants.
Adjusting for the other factors, the researchers found that heavy alcohol use was associated with 7-9 percent higher concentrations of DDE, oxychlordane, and trans-nonachlor in the women's blood plasma. Current smoking was associated with 10-19 percent higher concentrations of all four OCPs, and was highest for women who smoked ten or more cigarettes a day. Women who drank five or more glasses of water per day had 8-15 percent higher concentrations of all four OCPs, but especially trans-nonachlor, compared to women who drank two glasses of water or fewer per day.
The researchers also found evidence of exposure when the women were infants in the late 1970s and early-to-mid 1980s, the period when these pesticides were being banned. Study participants who were older had higher OCP concentrations, with each five-year age increment associated with 24 percent higher oxychlordane and 26 percent higher trans-nonachlor concentrations. Women who had been breastfed had 15 percent higher concentrations of DDE, 14 percent higher oxychlordane, and 15 percent higher trans-nonachlor than women who hadn't been breastfed.
Means for marijuana breathalyzer developed by researchers
https://newsroom.ucla.edu/releases/ucla-...eathalyzer
INTRO: UCLA chemists have reported the key chemical discovery necessary for the creation of a small, electronic marijuana breathalyzer. The research is published in Organic Letters, a peer-reviewed journal of the American Chemical Society.
The legalization and decriminalization of marijuana in California and elsewhere have made marijuana detection especially important, said senior author Neil Garg, UCLA’s Kenneth N. Trueblood Professor of Chemistry and Biochemistry and chair of UCLA’s department of chemistry and biochemistry.
“When I grew up, people were taught not to drive drunk,” Garg said. “I haven’t seen the same type of messages for marijuana yet, and statistics indicate more than 14 million people in the U.S. smoke marijuana and drive. Our goal was to devise a very simple solution that could be adopted by society. We have shown in this study we can change the chemical structure and properties of THC — the primary psychoactive ingredient in marijuana — using perhaps the simplest chemical means possible: electricity, to determine whether a person is impaired.”
“We want a simple breathalyzer that doesn’t require specialized training because a police officer is not a trained synthetic organic chemist,” said lead author Evan Darzi, a former postdoctoral scholar in Garg’s laboratory.
While Darzi and Garg have developed the chemistry that would be at the heart of a marijuana breathalyzer, they have not created an actual device. “We have established the fundamental proof of concept,” said Garg, who received the 2018 Robert Foster Cherry Award — which is the largest university teaching prize in the U.S., awarded by Baylor University — and was named the 2015 California Professor of the Year... (MORE)
https://www.youtube-nocookie.com/embed/MOAcMPcZrwQ
https://www.eurekalert.org/pub_releases/...050620.php
RELEASE: Over half of a cohort of 23-35-year-old black women from Detroit had detectable levels of organochlorine pesticides in their blood, possibly from tobacco, alcohol, and water.
A new Boston University School of Public Health (BUSPH) study published in the journal Environmental Research finds detectable levels of DDE (what DDT becomes when metabolized in the body) and other banned organochlorine pesticides (OCPs) in the blood of over 60 percent of a cohort of black women of reproductive age in the Detroit area, with higher levels in women who smoked cigarettes daily, drank more alcohol, and drank more water.
Dichlorodiphenyltrichloroethane (DDT) and other OCPs were banned decades ago. But they can dissolve into a person's body fat, and remain there for years, causing hormonal and metabolic issues, and even brain development issues from in-utero exposure.
"If cigarettes, alcohol, and drinking water are in fact exposing black women to pesticides, this matters!" says study lead author Dr. Olivia Orta, a postdoctoral research associate in the Department of Epidemiology at BUSPH. "The sources that we identified as potential OCP correlates should be tested for pesticide contamination," she says, "especially drinking water."
However, Orta cautions that the study was not able to distinguish between bottled and tap water, or test participants' tap water for these chemicals, so "we do not want to suggest that black women in Detroit reduce their water consumption in response to our study findings," she says. Instead, the study points to the importance of water monitoring--which has been notoriously inequitable, as seen in nearby Flint--and the need to test for OCPs in tap and bottled water as well as in alcohol and tobacco, she says.
Orta and colleagues used data from the Study of Environment, Lifestyle, and Fibroids (SELF), a prospective cohort study of reproductive-age black women recruited from the Detroit metropolitan area from 2010 to 2012. For the current study, the researchers analyzed blood samples from 742 fibroid-free participants, given when they entered the study, and their responses to questionnaires about health histories, demographics, behaviors, and other factors.
The researchers found detectable levels of four OCPs--dichlorodiphenyltrichloroethane (DDE), hexachlorobenzene (HCB), oxychlordane, and trans-nonachlor--in over 60 percent of the participants.
Adjusting for the other factors, the researchers found that heavy alcohol use was associated with 7-9 percent higher concentrations of DDE, oxychlordane, and trans-nonachlor in the women's blood plasma. Current smoking was associated with 10-19 percent higher concentrations of all four OCPs, and was highest for women who smoked ten or more cigarettes a day. Women who drank five or more glasses of water per day had 8-15 percent higher concentrations of all four OCPs, but especially trans-nonachlor, compared to women who drank two glasses of water or fewer per day.
The researchers also found evidence of exposure when the women were infants in the late 1970s and early-to-mid 1980s, the period when these pesticides were being banned. Study participants who were older had higher OCP concentrations, with each five-year age increment associated with 24 percent higher oxychlordane and 26 percent higher trans-nonachlor concentrations. Women who had been breastfed had 15 percent higher concentrations of DDE, 14 percent higher oxychlordane, and 15 percent higher trans-nonachlor than women who hadn't been breastfed.
Means for marijuana breathalyzer developed by researchers
https://newsroom.ucla.edu/releases/ucla-...eathalyzer
INTRO: UCLA chemists have reported the key chemical discovery necessary for the creation of a small, electronic marijuana breathalyzer. The research is published in Organic Letters, a peer-reviewed journal of the American Chemical Society.
The legalization and decriminalization of marijuana in California and elsewhere have made marijuana detection especially important, said senior author Neil Garg, UCLA’s Kenneth N. Trueblood Professor of Chemistry and Biochemistry and chair of UCLA’s department of chemistry and biochemistry.
“When I grew up, people were taught not to drive drunk,” Garg said. “I haven’t seen the same type of messages for marijuana yet, and statistics indicate more than 14 million people in the U.S. smoke marijuana and drive. Our goal was to devise a very simple solution that could be adopted by society. We have shown in this study we can change the chemical structure and properties of THC — the primary psychoactive ingredient in marijuana — using perhaps the simplest chemical means possible: electricity, to determine whether a person is impaired.”
“We want a simple breathalyzer that doesn’t require specialized training because a police officer is not a trained synthetic organic chemist,” said lead author Evan Darzi, a former postdoctoral scholar in Garg’s laboratory.
While Darzi and Garg have developed the chemistry that would be at the heart of a marijuana breathalyzer, they have not created an actual device. “We have established the fundamental proof of concept,” said Garg, who received the 2018 Robert Foster Cherry Award — which is the largest university teaching prize in the U.S., awarded by Baylor University — and was named the 2015 California Professor of the Year... (MORE)