Chinese Wuhan Virus

[Secular Sanity]

We’re the third runner up.

https://www.worldometers.info/coronavirus/

[C C]

Wuhan study: Body positioning can improve breathing in severe COVID-19 patients requiring ventilation
https://www.newswise.com/articles/wuhan-...entilation

INTRO: In a new study of patients with severe COVID-19 (SARS-CoV-2) hospitalized on ventilators, researchers found that lying face down was better for the lungs. The research letter was published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

In “Lung Recruitability in SARS—CoV-2 Associated Acute Respiratory Distress Syndrome: A Single-Center, Observational Study,” Haibo Qiu, MD, Chun Pan, MD, and co-authors report on a retrospective study of the treatment of 12 patients in Wuhan Jinyintan Hospital, China, with severe COVID-19 infection-related acute respiratory distress syndrome (ARDS) who were assisted by mechanical ventilation. Drs. Qiu and Pan were in charge of the treatment of these patients, who were transferred from other treatment centers to Jinyintan Hospital... (MORE)

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Which Covid-19 drugs work best?
https://www.technologyreview.com/s/61539...-outbreak/

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Infectious disease experts don’t know how bad the coronavirus is going to get, either
https://fivethirtyeight.com/features/inf...et-either/

[confused2]

One of the elephants in the garden looks to be "How many of these people would have died in the near future regardless of coronavirus?".
Another of the elephants wants to know "How many reasonably healthy people die without the aid of respirators?".

Snowflake + respirator = good chance of living
Snowflake + no respirator = ?

Boomer + respirator = still good chance of living
Boomer + no respirator = ?

Still no indication of average time hooked up to a respirator.
Clue - how many respirators does your country have?

Do you (me/they) die hooked up to a respirator?
Do they disconnect you as not worth saving? (still respirating but the chickens have flown the coop?)

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from https://www.bbc.co.uk/news/world-us-canada-52012048

The governor [of New York] blasted the 400 ventilators sent to New York from the US Federal Emergency Management Agency.
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He said: "You pick the 26,000 people who are going to die because you only sent 400 ventilators."

New York currently has 7,000 ventilators, but needs 30,000, the governor said.
Mr Cuomo continued: "The [infection] forecaster said to me, 'We were looking at a freight train coming across the country.'

"'We're now looking at a bullet train.'"

The state is also looking into creating more healthcare areas, possibly by turning college dormitories and hotels into makeshift hospitals.

[C C]

Pregnant in a pandemic: how will coronavirus affect me and my baby?
https://www.theguardian.com/us-news/2020...nd-my-baby

With antenatal classes canceled, doctor’s offices closing and restrictions on non-patients, such as fathers, Covid-19 has added a whole new level of anxiety to my first pregnancy.

[Zinjanthropos]

I walk out my front door and in a couple minutes I can gaze across the Niagara River and see NY state. I look at the numbers, watch a little tv and can't help wondering what in hell is going on over there. So glad they closed the border but now I hear Trump thinking about opening them up soon. I can't think of why anyone classed non-essential would want to go there and I certainly don't want people from NY state coming here if they don't have to. Hoping Trudeau says nyet to reopening borders here. Internationally there are 4 road and one railway bridge along river, both coast guards patrol river and there's cameras about. People have been known to boat across or crawl along under bridges. We also have the Welland canal which is open but not sure what the law is with respect to people coming ashore. I do know that Canadian boat pilots are required for passage.

For the most part Canadians here are in self imposed 14 day isolation but essential businesses are open and only take out food can be purchased at restaurants. A week to go. Lucky I'm not in a neighbourhood with houses close to one another. I'm expecting even more time will be required. Sure we have some assholes too but law getting much tougher every hour it seems. I wouldn't be surprised to see Armed Forces vehicles on the road anytime soon. I'm ok with it.

Actually I didn't realize how much work/repairs around house I've neglected so that's what I do to keep busy. So far a little every day seems to be making days go by faster. Next task for me is get up in a poplar tree that's more like two trees because it splits off at the base into two trunks of equal size. Trouble is the pair run east-west and I'm afraid a strong prevailing wind will blow the east trunk over onto the house (it leans that way). Need couple good days of weather and take my time up there with a saw or axe. Have to substantially trim down that one side to remove the danger. Not getting any younger.

[C C]

Missing link in coronavirus jump from bats to humans could be pangolins, not snakes - American Chemical Society
https://www.acs.org/content/acs/en/press...nakes.html

As scientists scramble to learn more about the SARS-CoV-2 coronavirus, two recent studies of the virus’ genome reached controversial conclusions: namely, that snakes are intermediate hosts of the new virus, and that a key coronavirus protein shares “uncanny similarities” with an HIV-1 protein. Now, a study in ACS’ Journal of Proteome Research refutes both ideas and suggests that scaly, anteater-like animals called pangolins are the missing link for SARS-CoV-2 transmission between bats and humans.

[Secular Sanity]

Missing link in coronavirus jump from bats to humans could be pangolins, not snakes - American Chemical Society
https://www.acs.org/content/acs/en/press...nakes.html

As scientists scramble to learn more about the SARS-CoV-2 coronavirus, two recent studies of the virus’ genome reached controversial conclusions: namely, that snakes are intermediate hosts of the new virus, and that a key coronavirus protein shares “uncanny similarities” with an HIV-1 protein. Now, a study in ACS’ Journal of Proteome Research refutes both ideas and suggests that scaly, anteater-like animals called pangolins are the missing link for SARS-CoV-2 transmission between bats and humans.

I thought it was a good candidate, too, given the myth that their scales contain opiates, but researches aren't convinced.


Not close enough

"Three similar comparison studies were posted on bioRxiv last week. One of those papers — by an international research group , posted on 18 February — found2 that coronaviruses in frozen cell samples from illegally trafficked pangolins shared between 85.5% and 92.4% of their DNA with the virus found in humans.

Two other papers published on 20 February, from groups in China, also studied coronaviruses from smuggled pangolins. The viruses were 90.23%3 and 91.02%4 similar, respectively, to the virus that causes COVID-19.

The genetic similarity should be higher than reported in these studies before the host can be identified, says Arinjay Banerjee, who studies coronaviruses at McMaster University in Hamilton, Canada. He notes that the SARS virus shared 99.8% of its genome with a civet coronavirus, which is why civets were considered the source. If pangolins are the origin of the current outbreak, says Banerjee, it is not the pangolins in these studies."

https://www.nature.com/articles/d41586-020-00548-w

Edit: I did read an article, though, that said the national agencies in China suspended the sale of all animals possibly linked to the coronavirus. It said that the statement specified badgers and bamboo rats. Both of which were sold in the market in Wuhan.

[Zinjanthropos]

Sold every stock I had when the virus starting getting big. Everything sitting in cash and I'm not moving on it for a while despite some tempting plays right now. Only kept a couple of small pharma stocks just in case one of them contributed to fighting the virus and I reap a bonanza. My wife might need it if I croak because of covid.  

One of these stocks is a company called Resverlogix. They put out the following news on March 24 but no big rise in share price followed. I don't know about medical science so could someone help interpret this news? Does it mean anything? Could they help with their product?

https://www.resverlogix.com/investors/news?article=662

[C C]

Sold every stock I had when the virus starting getting big. Everything sitting in cash and I'm not moving on it for a while despite some tempting plays right now. Only kept a couple of small pharma stocks just in case one of them contributed to fighting the virus and I reap a bonanza. My wife might need it if I croak because of covid.  

One of these stocks is a company called Resverlogix. They put out the following news on March 24 but no big rise in share price followed. I don't know about medical science so could someone help interpret this news? Does it mean anything? Could they help with their product?

https://www.resverlogix.com/investors/news?article=662

Purely a quick "glance over" opinion here rather than any deep investigation.

Apabetalone was originally developed for testing in treatment of atherosclerosis and associated cardiovascular disease, with maybe effects in other medical conditions. It's being repurposed with what sounds like a crowd of 68 other drugs that might similarly interfere with protein to protein interactions that COVID-19 potentially utilizes or depends upon in its replication process. Has to undergo further trials to ascertain its viral efficacy. Along with what seems likely that -- if approved -- it would be competing for popularity with the rest of that set of other drug candidates (however many of those pass).

[confused2]

Audit by KPMG

( https://www.resverlogix.com/investors/fi...ports#2019 )

Consolidated Financial Statements
Years ended April 30, 2019 and 2018We draw attention to Note 3 in the financial statements, which indicates that the
Entity has insufficient cash to fulfill its contractual commitments and to fund its
planned business operations over the next 12 months.
As stated in Note 3 in the financial statements, these events or conditions, along
with other matters as set forth in Note 3 in the financial statements, indicate that
a material uncertainty exists that may cast significant doubt on the Entity's ability
to continue as a going concern.

They might just be the guys who have found a new way to squeeze a snake to get the right oil out.

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from
https://www.bbc.co.uk/news/technology-52053565

Data collected gathered via the NHS's 111 telephone service is to be mixed with other sources to help predict where ventilators, hospital beds, and medical staff will be most in need.
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Three US tech firms are aiding the effort - Amazon, Microsoft and Palantir - as well as London-based Faculty AI.

Big data to the rescue.