New Alzheimer's vaccine

#1
"Their new vaccine for the first time has targeted both amyloid-containing plaques and tau—both considered hallmarks for a definitive identification of Alzheimer’s disease—in a mouse with the disease.

The shot uses DNA from Alzheimer's proteins to teach the immune system to fight these compounds and keep them from accumulating in the brain. Researchers say their new Alzheimer's vaccine—so-called DNA Aβ42—could conceivably cut the number of dementia cases in half."---
https://www.forbes.com/sites/robinseaton...e9b9b97e8f
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#2
There had better be a vaccination pit-stop for me by the time I swerve around the corner someday. Heck, "I forgot to take out the trash" has ramped up to a whole new level of absent-minded exploits, like it's a race to see which of us qualifies first.

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#3
(Nov 30, 2018 10:29 PM)C C Wrote: There had better be a vaccination pit-stop for me by the time I swerve around the corner someday. Heck, "I forgot to take out the trash" has ramped up to a whole new level of absent-minded exploits, like it's a race to see which of us qualifies first.

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look at the science over the last few decades around metabolising vitamins & critical amino acids.
traditionally retirement which meant a reduction in mental exercise and a huge reduction in general exercise should show big gains.

those still craming down trans fats and heavy antogonist things like raw red meat are likely to not fair so well.
attempting to assign shockingly poor diet and lack of mental exercise as a big data is not helpful.
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#4
Genetic predisposition may often need environmental triggers. Better hygiene in wealthy nations has even been blamed as either stimulus or cause for it. Everybody did lead dirtier and less sanitary lives before the 20th century, but dementia in general has been transpiring throughout history. A larger percentage of people just live longer today into the deterioration of old age, inviting a multifarious gamut of psychological and physiological ailments. No surprise there.

But an increase in early onset dementia is what's historically atypical or alarming. While genetic factors are the known culprit, it's the "unknown" territory (which includes encountering triggers for the former a lot sooner) that would seem to be responsible for a growing epidemic at younger ages. Aside from insomnia, familiar hypotheses in that direction run along the line of teenage and twenty-something indulgence in alcohol, antipsychotic medication, illicit drugs, sedentary gaming and edacious lifestyles that generate high blood pressure, obesity, etc.)

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#5
CC Wrote:There had better be a vaccination pit-stop for me by the time I swerve around the corner someday. Heck, "I forgot to take out the trash" has ramped up to a whole new level of absent-minded exploits, like it's a race to see which of us qualifies first.
Likewise. Incidentally your gif's are just mind-blowing. Apparently forgetting to turn the ring off on the cooker is one of the syptoms. I might be losing the ability to make porridge but sure as hell I turn the ring off after I've done it.
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#6
(Dec 3, 2018 01:35 AM)confused2 Wrote:
CC Wrote:There had better be a vaccination pit-stop for me by the time I swerve around the corner someday. Heck, "I forgot to take out the trash" has ramped up to a whole new level of absent-minded exploits, like it's a race to see which of us qualifies first.

Likewise. Incidentally your gif's are just mind-blowing. Apparently forgetting to turn the ring off on the cooker is one of the syptoms. I might be losing the ability to make porridge but sure as hell I turn the ring off after I've done it.


Reminds me of a broken clothes dryer my parents had that no longer automatically shut itself off. Naturally my brother evaded being assigned a hovering watchdog of it for the weeks till it finally got replaced or repaired (can't remember which). Even in youth, any initial confidence I had about not becoming distracted enough to forget about the thing running was easily shattered the first go-around. And now these years (eons?) later, such a promising spectacle of mental decline to come...

When deep in the throes of "recent decades" memory loss someday, I'm not sure how I'll construe a robot caregiver. Given the anachronistic situation of my psychologically dwelling in the past before droids had a competent presence in everyday life.

LEANING ON A CANE: "Can you perform soccer mom duties, Rosie? Elroy needs to be picked-up at school, after practice."

ROSIE: "Mrs Jetson, your son is 58 years old now. He's the principal there."

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#7
(Dec 3, 2018 01:35 AM)confused2 Wrote:
CC Wrote:There had better be a vaccination pit-stop for me by the time I swerve around the corner someday. Heck, "I forgot to take out the trash" has ramped up to a whole new level of absent-minded exploits, like it's a race to see which of us qualifies first.
Likewise. Incidentally your gif's are just mind-blowing. Apparently forgetting to turn the ring off on the cooker is one of the syptoms. I might be losing the ability to make porridge but sure as hell I turn the ring off after I've done it.


Negligently forgot to add this in whatever meandering chatter of my other reply.

Among the downloadable gif software options out there for those who want to make their own "dynamic avatars" offline is Cyotek's. They have a gif animator still passing through developmental stages, which features all the subtle adjustments of the ancient MS Gif Animator (a legacy artifact which itself amazingly still works on Win10). Plus the former has better capabilities like quickly transferring a thumbnail frame (that still needs additional work) to a robust graphics editor and back [such as GIMP, Paint-Dot-Net (with its ambitious plugins installed), etc]. No doubt there are paid products that are similarly loaded with gif adjustments which other freeware are missing, but hardly initially inviting to those who just want to get their feet wet and tinker.

Oh, and RIOT would be essential for reducing the number of bytes for each frame and insuring that they don't get badly mangled in the process. Heck, I believe Paint-Dot-Net even has RIOT as a plugin or something. Would be found somewhere here in the plugin index subforum.

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