Jun 8, 2026 05:57 PM
https://www.sciencealert.com/huge-psiloc...ia-patient
EXCERPT: The elderly woman with dementia was first treated with an incredibly high dose of 5 grams of psilocybin-containing mushrooms, which caused her to enter a prolonged, deep sleep-like state.
Before the experimental treatment, the patient could only speak in monosyllables, rarely initiated communication with others, and was very dependent on assistance for basic activities of daily living.
Roughly 19 hours after the oral dose, the woman suddenly began to talk to herself. She kept doing so for several hours. Over the next few days, the elderly patient was reportedly able to control her bladder, dress and walk by herself, and engage in conversation, holding eye contact and smiling back.
"The persistence of urinary continence after more than 5 years of chronic incontinence is particularly notable, given that continence depends on integrated interoceptive awareness, executive inhibition, and fronto-insular network function," write the researchers behind her case report, including neurologists Mariana Cerveira and Joe Xavier Simonet.
Because of the woman's promising and lingering response to psilocybin, she was administered another 3 grams of mushrooms a month after the first session. This dose was also closely supervised.
During the second session, the patient did not fall asleep but remained verbally expressive throughout. She described emotional scenes, like surfing with her son on a peaceful island.
"Facial expressivity, emotional reciprocity, spontaneous humor, and gait agility appeared markedly improved," reads her case report. During this second session, the woman said, unprompted, "It is pleasant to come here."
It is important to note that researchers in Brazil did not monitor the woman's sleep state or brain activity during her trip, nor did they use standardized cognitive scales to assess her cognitive state... (MORE - details)
EXCERPT: The elderly woman with dementia was first treated with an incredibly high dose of 5 grams of psilocybin-containing mushrooms, which caused her to enter a prolonged, deep sleep-like state.
Before the experimental treatment, the patient could only speak in monosyllables, rarely initiated communication with others, and was very dependent on assistance for basic activities of daily living.
Roughly 19 hours after the oral dose, the woman suddenly began to talk to herself. She kept doing so for several hours. Over the next few days, the elderly patient was reportedly able to control her bladder, dress and walk by herself, and engage in conversation, holding eye contact and smiling back.
"The persistence of urinary continence after more than 5 years of chronic incontinence is particularly notable, given that continence depends on integrated interoceptive awareness, executive inhibition, and fronto-insular network function," write the researchers behind her case report, including neurologists Mariana Cerveira and Joe Xavier Simonet.
Because of the woman's promising and lingering response to psilocybin, she was administered another 3 grams of mushrooms a month after the first session. This dose was also closely supervised.
During the second session, the patient did not fall asleep but remained verbally expressive throughout. She described emotional scenes, like surfing with her son on a peaceful island.
"Facial expressivity, emotional reciprocity, spontaneous humor, and gait agility appeared markedly improved," reads her case report. During this second session, the woman said, unprompted, "It is pleasant to come here."
It is important to note that researchers in Brazil did not monitor the woman's sleep state or brain activity during her trip, nor did they use standardized cognitive scales to assess her cognitive state... (MORE - details)