Jan 3, 2025 06:50 PM
https://www.quantamagazine.org/scientist...-20250102/
INTRO: Far from being solo operators, most single-celled microbes are in complex relationships. In the ocean, the soil and your gut, they might battle and eat each other, exchange DNA, compete for nutrients, or feed on one another’s by-products. Sometimes they get even more intimate: One cell might slip inside another and make itself comfortable. If the conditions are just right, it might stay and be welcomed, sparking a relationship that could last for generations — or billions of years. This phenomenon of one cell living inside another, called endosymbiosis, has fueled the evolution of complex life.
Examples of endosymbiosis are everywhere. Mitochondria, the energy factories in your cells, were once free-living bacteria. Photosynthetic plants owe their sun-spun sugars to the chloroplast, which was also originally an independent organism. Many insects get essential nutrients from bacteria that live inside them. And last year researchers discovered the “nitroplast,” (opens a new tab) an endosymbiont that helps some algae process nitrogen.
So much of life relies on endosymbiotic relationships, but scientists have struggled to understand how they happen. How does an internalized cell evade digestion? How does it learn to reproduce inside its host? What makes a random merger of two independent organisms into a stable, lasting partnership?
Now, for the first time, researchers have watched the opening choreography of this microscopic dance by inducing endosymbiosis in the lab (opens a new tab). After injecting bacteria into a fungus — a process that required creative problem-solving (and a bicycle pump) — the researchers managed to spark cooperation without killing the bacteria or the host. Their observations offer a glimpse into the conditions that make it possible for the same thing to happen in the microbial wild.
The cells even adjusted to each other faster than anticipated. “To me, this means that organisms want to actually live together, and symbiosis is the norm,” said Vasilis Kokkoris (opens a new tab), a mycologist who studies the cell biology of symbiosis at VU University in Amsterdam and wasn’t involved in the new study. “So that’s big, big news for me and for this world.”
Early attempts that fell short reveal that most cellular love affairs are unsuccessful. But by understanding how, why and when organisms accept endosymbionts, researchers can better understand key moments in evolution, and also potentially develop synthetic cells engineered with superpowered endosymbionts... (MORE - details)
INTRO: Far from being solo operators, most single-celled microbes are in complex relationships. In the ocean, the soil and your gut, they might battle and eat each other, exchange DNA, compete for nutrients, or feed on one another’s by-products. Sometimes they get even more intimate: One cell might slip inside another and make itself comfortable. If the conditions are just right, it might stay and be welcomed, sparking a relationship that could last for generations — or billions of years. This phenomenon of one cell living inside another, called endosymbiosis, has fueled the evolution of complex life.
Examples of endosymbiosis are everywhere. Mitochondria, the energy factories in your cells, were once free-living bacteria. Photosynthetic plants owe their sun-spun sugars to the chloroplast, which was also originally an independent organism. Many insects get essential nutrients from bacteria that live inside them. And last year researchers discovered the “nitroplast,” (opens a new tab) an endosymbiont that helps some algae process nitrogen.
So much of life relies on endosymbiotic relationships, but scientists have struggled to understand how they happen. How does an internalized cell evade digestion? How does it learn to reproduce inside its host? What makes a random merger of two independent organisms into a stable, lasting partnership?
Now, for the first time, researchers have watched the opening choreography of this microscopic dance by inducing endosymbiosis in the lab (opens a new tab). After injecting bacteria into a fungus — a process that required creative problem-solving (and a bicycle pump) — the researchers managed to spark cooperation without killing the bacteria or the host. Their observations offer a glimpse into the conditions that make it possible for the same thing to happen in the microbial wild.
The cells even adjusted to each other faster than anticipated. “To me, this means that organisms want to actually live together, and symbiosis is the norm,” said Vasilis Kokkoris (opens a new tab), a mycologist who studies the cell biology of symbiosis at VU University in Amsterdam and wasn’t involved in the new study. “So that’s big, big news for me and for this world.”
Early attempts that fell short reveal that most cellular love affairs are unsuccessful. But by understanding how, why and when organisms accept endosymbionts, researchers can better understand key moments in evolution, and also potentially develop synthetic cells engineered with superpowered endosymbionts... (MORE - details)