Sep 9, 2024 05:45 PM
https://www.eurekalert.org/news-releases/1057009
INTRO: Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development. When androgen receptor binds with NSD2, it causes rapid cell division and growth leading to prostate cancer. The study, published in Nature Genetics, may suggest a new way to therapeutically target prostate cancer.
The findings illuminate a phenomenon not previously understood. The androgen receptor’s normal function is to define the development of the prostate. It tells the cells to stop growing and maintain a normal prostate. But in cancer, androgen receptor does the opposite: it tells the cells to continue growing and drive cancer development... (MORE - details, no ads)
INTRO: Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development. When androgen receptor binds with NSD2, it causes rapid cell division and growth leading to prostate cancer. The study, published in Nature Genetics, may suggest a new way to therapeutically target prostate cancer.
The findings illuminate a phenomenon not previously understood. The androgen receptor’s normal function is to define the development of the prostate. It tells the cells to stop growing and maintain a normal prostate. But in cancer, androgen receptor does the opposite: it tells the cells to continue growing and drive cancer development... (MORE - details, no ads)