Jan 10, 2024 07:08 PM
(This post was last modified: Jan 10, 2024 07:26 PM by C C.)
CAUTION: Too much vitamin D can cause kidney stones and other problems if you have low kidney function or are elderly, due to it being a fat-soluble nutrient that doesn't flush out as easily as others (consequently can be stored and build-up in tissues). ---> Vitamin D toxicity. With respect to the latter, if you are on anti-coagulant or blood-thinner medication, it is deadly to take vitamin-K (period) in conjunction with vitamin-D as a dubious option to alleviate overdose potential. K is also fat-soluble.
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Major Study Identifies 15 Factors Linked to Early Dementia Risk
https://www.sciencealert.com/major-study...entia-risk
INTRO: While dementia is much more common in older adults, hundreds of thousands of people are diagnosed with young-onset dementia (YOD) each year – and an extensive new study sheds some considerable new light on why.
Most previous research in this area has looked at genetics passed down through generations, but here, the team was able to identify 15 different lifestyle and health factors that are associated with YOD risk.
"This is the largest and most robust study of its kind ever conducted," says epidemiologist David Llewellyn from the University of Exeter in the UK. "Excitingly, for the first time it reveals that we may be able to take action to reduce risk of this debilitating condition, through targeting a range of different factors."
The research team analyzed data collected on 356,052 people aged under 65 in the UK. Low socioeconomic status, social isolation, hearing impairment, stroke, diabetes, heart disease, and depression were all associated with a higher risk of YOD.
Vitamin D deficiency and high levels of the C-reactive protein (produced by the liver in response to inflammation) also meant a higher risk, as did having two of the ApoE4 ε4 gene variants (a genetic scenario already linked to Alzheimer's disease).
The researchers describe the relationship between alcohol and YOD as "complex". While alcohol abuse led to an increased risk, moderate to heavy drinking correlated with a reduced risk – possibly because people in this second group are usually healthier in general (bear in mind that those who abstain from alcohol often do so on medical grounds).
Higher levels of formal education and lower physical frailty (measured through higher handgrip strength) were also associated with a lower YOD risk... (MORE - details)
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Risk of young-onset dementia could be reduced through targeting health and lifestyle factors - study
https://news.exeter.ac.uk/faculty-of-hea...e-factors/
PRESS RELEASE: Researchers have identified a wide range of risk factors for young-onset dementia. The findings challenge the notion that genetics are the sole cause of the condition, laying the groundwork for new prevention strategies.
The largescale study identified 15 risk factors, which are similar to those for late-onset dementia. For the first time, they indicate that it may be possible to reduce the risk of young-onset dementia by targeting health and lifestyle factors.
Relatively little research has been done on young-onset dementia, though globally there are around 370,000 new cases of young-onset dementia each year.
Published in JAMA Neurology, the new research by the University of Exeter and Maastricht University followed more than 350,000 participants younger than 65 across the United Kingdom from the UK Biobank study. The team evaluated a broad array of risk factors ranging from genetic predispositions to lifestyle and environmental influences. The study revealed that lower formal education, lower socioeconomic status, genetic variation, lifestyle factors such as alcohol use disorder and social isolation, and health issues including vitamin D deficiency, depression, stroke, hearing impairment and heart disease significantly elevate risk of young-onset dementia
Professor David Llewellyn of the University of Exeter emphasized the importance of the findings: "This breakthrough study illustrates the crucial role of international collaboration and big data in advancing our understanding of dementia. There's still much to learn in our ongoing mission to prevent, identify, and treat dementia in all its forms in a more targeted way. This is the largest and most robust study of its kind ever conducted. Excitingly, for the first time it reveals that we may be able to take action to reduce risk of this debilitating condition, through targeting a range of different factors.
Dr Stevie Hendriks, Researcher at Maastricht University, said: “Young-onset dementia has a very serious impact, because the people affected usually still have a job, children, and a busy life. The cause is often assumed to be genetic, but for many people we don’t actually know exactly what the cause is. This is why we also wanted to investigate other risk factors in this study.”
Sebastian Köhler, Professor of Neuroepidemiology at Maastricht University, said: “We already knew from research on people who develop dementia at older age that there are a series of modifiable risk factors. In addition to physical factors, mental health also plays an important role, including avoiding chronic stress, loneliness and depression. The fact that this is also evident in young-onset dementia came as a surprise to me, and it may offer opportunities to reduce risk in this group too.”
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Major Study Identifies 15 Factors Linked to Early Dementia Risk
https://www.sciencealert.com/major-study...entia-risk
INTRO: While dementia is much more common in older adults, hundreds of thousands of people are diagnosed with young-onset dementia (YOD) each year – and an extensive new study sheds some considerable new light on why.
Most previous research in this area has looked at genetics passed down through generations, but here, the team was able to identify 15 different lifestyle and health factors that are associated with YOD risk.
"This is the largest and most robust study of its kind ever conducted," says epidemiologist David Llewellyn from the University of Exeter in the UK. "Excitingly, for the first time it reveals that we may be able to take action to reduce risk of this debilitating condition, through targeting a range of different factors."
The research team analyzed data collected on 356,052 people aged under 65 in the UK. Low socioeconomic status, social isolation, hearing impairment, stroke, diabetes, heart disease, and depression were all associated with a higher risk of YOD.
Vitamin D deficiency and high levels of the C-reactive protein (produced by the liver in response to inflammation) also meant a higher risk, as did having two of the ApoE4 ε4 gene variants (a genetic scenario already linked to Alzheimer's disease).
The researchers describe the relationship between alcohol and YOD as "complex". While alcohol abuse led to an increased risk, moderate to heavy drinking correlated with a reduced risk – possibly because people in this second group are usually healthier in general (bear in mind that those who abstain from alcohol often do so on medical grounds).
Higher levels of formal education and lower physical frailty (measured through higher handgrip strength) were also associated with a lower YOD risk... (MORE - details)
- - - - - - - - -
Risk of young-onset dementia could be reduced through targeting health and lifestyle factors - study
https://news.exeter.ac.uk/faculty-of-hea...e-factors/
PRESS RELEASE: Researchers have identified a wide range of risk factors for young-onset dementia. The findings challenge the notion that genetics are the sole cause of the condition, laying the groundwork for new prevention strategies.
The largescale study identified 15 risk factors, which are similar to those for late-onset dementia. For the first time, they indicate that it may be possible to reduce the risk of young-onset dementia by targeting health and lifestyle factors.
Relatively little research has been done on young-onset dementia, though globally there are around 370,000 new cases of young-onset dementia each year.
Published in JAMA Neurology, the new research by the University of Exeter and Maastricht University followed more than 350,000 participants younger than 65 across the United Kingdom from the UK Biobank study. The team evaluated a broad array of risk factors ranging from genetic predispositions to lifestyle and environmental influences. The study revealed that lower formal education, lower socioeconomic status, genetic variation, lifestyle factors such as alcohol use disorder and social isolation, and health issues including vitamin D deficiency, depression, stroke, hearing impairment and heart disease significantly elevate risk of young-onset dementia
Professor David Llewellyn of the University of Exeter emphasized the importance of the findings: "This breakthrough study illustrates the crucial role of international collaboration and big data in advancing our understanding of dementia. There's still much to learn in our ongoing mission to prevent, identify, and treat dementia in all its forms in a more targeted way. This is the largest and most robust study of its kind ever conducted. Excitingly, for the first time it reveals that we may be able to take action to reduce risk of this debilitating condition, through targeting a range of different factors.
Dr Stevie Hendriks, Researcher at Maastricht University, said: “Young-onset dementia has a very serious impact, because the people affected usually still have a job, children, and a busy life. The cause is often assumed to be genetic, but for many people we don’t actually know exactly what the cause is. This is why we also wanted to investigate other risk factors in this study.”
Sebastian Köhler, Professor of Neuroepidemiology at Maastricht University, said: “We already knew from research on people who develop dementia at older age that there are a series of modifiable risk factors. In addition to physical factors, mental health also plays an important role, including avoiding chronic stress, loneliness and depression. The fact that this is also evident in young-onset dementia came as a surprise to me, and it may offer opportunities to reduce risk in this group too.”