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Article  Primitive Asgard cells show life on the brink of complexity

#1
C C Offline
https://www.quantamagazine.org/primitive...-20230411/

EXCERPTS:  . . . But this was no complex cell. It looked more ancestral, primordial. The organism, first published in Nature, is only the second representative of a group of microbes called Asgard archaea to be grown and studied in detail. Coaxing it to grow out of a tiny spoonful of seafloor sludge, which took six years, was like preparing a dressing room for a temperamental celebrity. The organism couldn’t be centrifuged, stirred, exposed to oxygen, separated from a few other microbes it pals around with, or rushed into growing any faster than a glacial pace.

For months, it didn’t even grow at all. “I worried also for my own future in science,” said Thiago Rodrigues-Oliveira, who led the effort to cultivate the new species as a postdoc in Schleper’s lab, betting his own career on the whims of a single, recalcitrant organism.

As excruciatingly difficult as they are to deal with, the Asgard archaea are now among the most coveted organisms in science, and for good reason. To many evolutionary biologists, their discovery and subsequent studies justify revising the textbook pictures of the tree of life to situate us — and every other creature built from eukaryotic cells — as mere offshoots of the Asgard group.

[...] Within the now-dominant two-domain picture to which the Asgard archaea are contributing, the big story of life on this planet goes something like this. Some 4 billion years ago, life forked into two single-celled branches, the archaea and the bacteria.

Genetic evidence implies that the two branches crossed again 2 billion years later when an archaeon — likely from the Asgard group — somehow ingested a bacterium. The process domesticated what was once a distinct, free-living cell and turned it into the organelles called mitochondria that persist inside eukaryotic cells. The descendants of that fateful union branched into other single-celled organisms like dinoflagellates, and then later into multicellular creatures that grew to macroscopic sizes, left fossils behind, and colonized both sea and land.

But even theorists who stand behind this narrative belong to divided camps. Some argue that gaining mitochondria was the defining event in eukaryogenesis. Others insist that mitochondria arrived late in an ongoing transition... (MORE - missing details)
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#2
Kornee Offline
There's a persistent elephant in the room evo-bio types never afaik attempt to seriously address, re 'accidental swallowing of bacteria -> first eukaryote cell with nucleus':
How does this statistical freak chimera then go on to divide and reproduce more of the same? Miracle of miracles. But miracles are not allowed, so.....????
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#3
confused2 Offline
(Apr 14, 2023 07:26 AM)Kornee Wrote: There's a persistent elephant in the room evo-bio types never afaik attempt to seriously address, re 'accidental swallowing of bacteria -> first eukaryote cell with nucleus':
How does this statistical freak chimera then go on to divide and reproduce more of the same? Miracle of miracles. But miracles are not allowed, so.....????

The search for a 'least improbable' event doesn't seem to have found anything that looks very probable. One might guess that the "let's divide" signals were sufficiently similar in both organisms that some guests got carried away in every new host. Is that enough to explain the elephant?
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#4
Kornee Offline
(Apr 14, 2023 12:48 PM)confused2 Wrote: The search for a  'least improbable' event doesn't seem to have found anything that looks very probable. One might guess that the "let's divide" signals were sufficiently similar in both organisms that some guests got carried away in every new host. Is that enough to explain the elephant?
To 'explain' the exquisitely orchestrated sequence of events needed for cell mytosis? Umm...no. Here's a scholarly stab:
https://genomebiology.biomedcentral.com/...0-11-5-209
"The origin of eukaryotes is a huge enigma and a major challenge for evolutionary biology."
An honest start. Why continue reading past that point. It informs the rest will be hopeful speculation.
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