Thread Rating:
  • 0 Vote(s) - 0 Average
  • 1
  • 2
  • 3
  • 4
  • 5

The "prune effect" on bone nutrition + Is deadly poison a secret to life's emergence?

#1
C C Offline
Is deadly poison the secret to the emergence of life on Earth and elsewhere?
https://www.syfy.com/syfy-wire/earths-ea...-by-poison

INTRO: Generally speaking, it’s a good idea to stay a long way away from cyanide. A couple hundred milligrams, administered orally, is fatal within hours. Ingestion, either through digestion or respiration, brings on symptoms including confusion, vomiting, and injury to the heart and lungs. Even those who survive can have lifelong debilitating disease as a result. In short, it’s super bad stuff and doesn’t play well with biology. Which is why it’s so weird that it might have been an essential ingredient in the formation of life on Earth.

A recent paper by Ramanarayanan Krishnamurthy from the Department of Chemistry at the Scripps Research Institute, and colleagues, reveals that in addition to just absolutely murdering living things, cyanide is an excellent metabolic pathway for prebiotic chemistry. The results of the team’s research were published in the journal Nature Chemistry.

“Cyanide is one of the molecules which we think are a part of early atmospheres, including Earth’s,” Krishnamurthy told SYFY WIRE. “It can lead to the formation of amino acids and give rise to other building blocks.” (MORE - details)


Exploring the “prune effect” - nutrition research delves into the bone health benefits of prunes
https://www.eurekalert.org/news-releases/942812

RELEASE: In a new scientific review published in Advances in Nutrition titled “The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women,” researchers from Pennsylvania State University examined the relationships between bone health, oxidative stress, inflammation, gut health, and prune consumption. In an analysis and synthesis of more than 18 studies, researchers acknowledge an existing link between prunes and bone health and propose future research to further understand the mechanisms behind the fruit’s positive impacts on bone via suppression of oxidative stress and inflammatory markers, as well as gut microbiota changes.

“Osteoporosis represents a major public health issue with women over 50 years old. Non-pharmaceutical nutritional interventions are becoming increasingly popular, and prunes have been extensively studied as a potential intervention in some populations,” said lead author of the review, Connie J. Rogers, PhD, MPH, Associate Professor of Nutritional Sciences and Physiology, Pennsylvania State University. “There is increasing evidence that the bone protective effects of prunes may be connected to their antioxidant and anti-inflammatory activity, and it is possible that changes to the gut from eating prunes may also be involved in favorable bone outcomes.”

Drawing from both clinical and preclinical trials, researchers suggest that the phenolic compounds and dietary fiber content in prunes may alter the gut microbiome in a manner that decreases the circulation of inflammatory markers, ultimately improving bone turnover. They also propose that the phenolic compounds in prunes may be responsible for antioxidant activity that helps slow the processes involved in bone loss and potentially promotes bone formation.

Clinical trials in postmenopausal women have shown the promising effects of prunes on bone health outcomes, indicating that prune consumption at both 50 grams and 100 grams per day may prevent bone loss. Additionally, research on the relationship between inflammation and prune consumption also suggests prunes’ positive effect on antioxidant capacity and decreases in some inflammatory markers in postmenopausal women with bone loss.

Rogers and her team recommend building on these existing studies by performing larger scale randomized controlled prune consumption trials that include measuring phenolic compounds via blood or urine to further explore changes in oxidation, inflammation and the gut microbiome. In doing so, researchers can more closely and more accurately determine the different pathways prunes may impact in the body and how they lead to improved bone health.

To view the abstract of the review, click here.
Reply
#2
Kornee Offline
(Feb 9, 2022 02:13 AM)C C Wrote: Is deadly poison the secret to the emergence of life on Earth and elsewhere?
https://www.syfy.com/syfy-wire/earths-ea...-by-poison

INTRO: Generally speaking, it’s a good idea to stay a long way away from cyanide. A couple hundred milligrams, administered orally, is fatal within hours. Ingestion, either through digestion or respiration, brings on symptoms including confusion, vomiting, and injury to the heart and lungs. Even those who survive can have lifelong debilitating disease as a result. In short, it’s super bad stuff and doesn’t play well with biology. Which is why it’s so weird that it might have been an essential ingredient in the formation of life on Earth.

A recent paper by Ramanarayanan Krishnamurthy from the Department of Chemistry at the Scripps Research Institute, and colleagues, reveals that in addition to just absolutely murdering living things, cyanide is an excellent metabolic pathway for prebiotic chemistry. The results of the team’s research were published in the journal Nature Chemistry.

“Cyanide is one of the molecules which we think are a part of early atmospheres, including Earth’s,” Krishnamurthy told SYFY WIRE. “It can lead to the formation of amino acids and give rise to other building blocks.” (MORE - details)

The first linked article above in turn cited this one:
https://associationofanaesthetists-publi...00.01628.x
which 2008 (14 years ago!) article contains:
"Cyanide is one of the earliest organic molecules ever detected in space and is an essential precursor in the synthesis of amino acids, purines and pyrimidines [1]"
So the apparent 'new discovery' re role of cyanide as catalyst for amino acid production etc. is obviously far from new. Hype -> hoped for continued research grants?
Reply
#3
Syne Offline
(Feb 9, 2022 02:13 AM)C C Wrote: “Cyanide is one of the molecules which we think are a part of early atmospheres, including Earth’s,” Krishnamurthy told SYFY WIRE. “It can lead to the formation of amino acids and give rise to other building blocks.”

And? Until someone can manage to show the leap from amino acids and other building blocks to actual life, it means nothing about the "emergence of life on Earth."
Reply
#4
Kornee Offline
Quite so. Some with entrenched prejudices against 'ID' might do well to start on part 1 of a YT reeducation course:
https://www.youtube.com/watch?v=NqoVxwdWWpg
Maybe a new thread is in order, but let's see if above garners any real interest. Unlikely because entrenched really does mean entrenched.
Reply
#5
Syne Offline
From a brief viewing, it seems pretty solid. Debunking claims about abiogenesis and the way people conflate it with evolution is a good start. Not very likely to change the mind of a materialist ideologue though. Personally, I believe in theistic evolution rather than intelligent design.
Reply
#6
Kornee Offline
This imo largely gets down to one's own definitions - what exactly distinguishes ID from Theistic Evolution? The distinction is clear enough if one is a Young Earth ID idealog. But for those acknowledging that the Earth and Universe are quite ancient, it all hinges on subtleties and fine distinctions. For me the line is blurred. I see it as a very complex, hidden-to-humans amalgam of macro ID interventions, coupled with micro evolution refinements. Also, 'evolution', once the strict domain of already living organisms, has now expanded to include prebiotic chemistry. James tour, among others with lesser presentation panache, has killed prebiotic evolution with ruthless logic.

What though about traditional Darwinian evolution? The prevailing scientism ideology insists no supernatural influence is either necessary or worthy of serious consideration.
World superstar David Attenborough for instance, provides a fascinating purview of the incredibly specialized and highly coordinated all-or-nothing attributes of say a Venus Flytrap plant.
Invariably he hand-waves the obvious multiple chicken-and-egg dilemmas off with 'over millions of years'... Ha ha. NO - it's really a do or die, all or nothing situation, but that fatal flaw is never allowed to take root in the public's mind. Slick presentation wins the day - every time.

Many think that Michael Behe of 'Darwin's Black Box' fame has been thoroughly discredited decades ago. The opposite is the case, but who is aware of it?
https://evolutionnews.org/2019/02/train-...n-science/
Reply
#7
Syne Offline
Yes, ID and TE are blurry for the non-ideologue. Personally, it could also be the appearance of evolution (theistic or otherwise) created in one fell swoop..perhaps to preserve the question of God's existence and necessary free will to choose. Evolutionary scientists have come no where near demonstrating a completely natural evolution. Excuses about the convenient gaps in the fossil record do not cut it. While speciation can be demonstrated, they can often still interbreed and it's a far cry from explaining speciation that leads to entirely different genus or family, much less order, kingdom, etc..
Reply
#8
Kornee Offline
(Feb 16, 2022 03:42 AM)Syne Wrote: Yes, ID and TE are blurry for the non-ideologue. Personally, it could also be the appearance of evolution (theistic or otherwise) created in one fell swoop..perhaps to preserve the question of God's existence and necessary free will to choose. Evolutionary scientists have come no where near demonstrating a completely natural evolution. Excuses about the convenient gaps in the fossil record do not cut it. While speciation can be demonstrated, they can often still interbreed and it's a far cry from explaining speciation that leads to entirely different genus or family, much less order, kingdom, etc..

Agreed. Except for the problematic possibility of Divinely crafted 'apparent unbroken natural evolution'. It could be the case, but creates a moral dilemma - a God of Truth who uses deception to test one's faith.
Amusingly, Young Earth creationists are forced to follow that route - especially when it comes to 'harmonizing' real astronomy/cosmology with a YE/YC of ~ 6000 years age! Which some can somehow stretch to ~ 10000 years.
Strict OT genealogies be dammed! Ha ha ha - eat the cake or keep it - can't have both. Big Grin
Reply
#9
Syne Offline
(Feb 16, 2022 05:56 AM)Kornee Wrote:
(Feb 16, 2022 03:42 AM)Syne Wrote: Yes, ID and TE are blurry for the non-ideologue. Personally, it could also be the appearance of evolution (theistic or otherwise) created in one fell swoop..perhaps to preserve the question of God's existence and necessary free will to choose. Evolutionary scientists have come no where near demonstrating a completely natural evolution. Excuses about the convenient gaps in the fossil record do not cut it. While speciation can be demonstrated, they can often still interbreed and it's a far cry from explaining speciation that leads to entirely different genus or family, much less order, kingdom, etc..

Agreed. Except for the problematic possibility of Divinely crafted 'apparent unbroken natural evolution'. It could be the case, but creates a moral dilemma - a God of Truth who uses deception to test one's faith.
Amusingly, Young Earth creationists are forced to follow that route - especially when it comes to 'harmonizing' real astronomy/cosmology with a YE/YC of ~ 6000 years age! Which some can somehow stretch to ~ 10000 years.
Strict OT genealogies be dammed! Ha ha ha - eat the cake or keep it - can't have both. Big Grin

Yeah, that's what I meant by "the appearance of evolution (theistic or otherwise)." Not sure I'd call that deception, as some atheists would probably claim god not showing itself to be deception by omission. If god's plan is to leave zero actual evidence of its existence, that might be necessary. But until science can really demonstrate some fundamentals about evolution, we're nowhere near putting that to the test.
Reply


Possibly Related Threads…
Thread Author Replies Views Last Post
  Discovery of new highly virulent HIV variant + Losing poison diversity with phib loss C C 0 71 Feb 4, 2022 01:54 AM
Last Post: C C
  BF + Why single people smell different + Secret workings of smell receptors revealed C C 0 120 Jun 22, 2021 07:27 PM
Last Post: C C
  Bacteria in a Dinosaur Bone Reignite a Heated Debate C C 0 400 Sep 14, 2018 04:00 PM
Last Post: C C
  The secret life of trees Magical Realist 1 510 Oct 12, 2016 11:08 PM
Last Post: C C
  Beetle with Deadly Machine-Gun Butt Yazata 6 1,641 May 6, 2015 06:27 PM
Last Post: Mr Doodlebug



Users browsing this thread: 1 Guest(s)