Losing amphibian diversity also means losing poison diversity
https://www.eurekalert.org/news-releases/942283
INTRO: While frog and salamander declines worldwide have made scientists outspoken about the need to preserve amphibian genetic diversity, two University of California, Berkeley, biologists emphasize another important reason for conserving these animals: their poisons.
In a recent review of an endangered group — the colorful, yet poisonous, harlequin toads of Central and South America — Rebecca Tarvin and Kannon Pearson emphasize how little is known about the toxins these animals produce or sequester, or why they have them at all. Yet, of the 113 known species of harlequin toads, most are in decline, and a quarter may already be extinct.
Given that animal toxins have proved to be a useful source of pharmaceuticals — drugs already on the market derive from snake and snail venom, while toxins from the pufferfish, centipede and scorpion are in trials — inspiration for new drugs will be lost, along with the animals.
“In Central America, there's nine species of Atelopus, and seven of them have been assessed for toxin diversity and quantity,” said Tarvin, UC Berkeley assistant professor of integrative biology. “But the majority of the Atelopus species actually live in South America, where a minority of the studies have been done. There are entire countries, like Bolivia and Guyana, where not a single species has been assessed. We don't know of any reports of whether Indigenous people use them. We don't know if they're toxic or not. One of the takeaways from our paper is that by losing these animals, we're probably losing some chemical diversity, as well. They have some toxins that are found nowhere else in the world.” (MORE - details)
Discovery of new highly virulent and damaging HIV variant in the Netherlands
https://www.eurekalert.org/news-releases/941678
RELEASE: As the ongoing coronavirus pandemic has demonstrated, new mutations in viral genetic sequences can have significant impacts on the virus’s transmissibility and the damage it causes. For many years, there have been concerns that this could arise in the HIV-1 virus, which already affects 38 million people worldwide, and has caused 33 million deaths to date (www.unaids.org). This has now been confirmed with the discovery of a new, highly virulent HIV strain in the Netherlands, in a study led by researchers from the University of Oxford’s Big Data Institute. The results are published today in Science.
Individuals infected with the new “VB variant” (for virulent subtype B) showed significant differences before antiretroviral treatment compared with individuals infected with other HIV variants:
Further research to understand the mechanism that causes the VB variant to be more transmissible and damaging to the immune system could reveal new targets for next-generation antiretroviral drugs. The VB variant is characterized by many mutations spread throughout the genome, meaning that a single genetic cause cannot be identified at this stage.
Lead author Dr Chris Wymant, from the University of Oxford’s Big Data Institute and Nuffield Department of Medicine, said: ‘Before this study, the genetics of the HIV virus were known to be relevant for virulence, implying that the evolution of a new variant could change its impact on health. Discovery of the VB variant demonstrated this, providing a rare example of the risk posed by viral virulence evolution.’
Senior author Professor Christophe Fraser from the University of Oxford’s Big Data Institute and Nuffield Department of Medicine, added: ‘Our findings emphasise the importance of World Health Organization guidance that individuals at risk of acquiring HIV have access to regular testing to allow early diagnosis, followed by immediate treatment. This limits the amount of time HIV can damage an individual’s immune system and jeopardise their health. It also ensures that HIV is suppressed as quickly as possible, which prevents transmission to other individuals.’
The VB variant was first identified in 17 HIV positive individuals from the BEEHIVE project, an ongoing study which collects samples from across Europe and Uganda. Since 15 of these people came from the Netherlands, the researchers then analysed data from a cohort of over 6,700 HIV positive individuals in the Netherlands. This identified an additional 92 individuals with the variant, from all regions of the Netherlands, bringing the total to 109.
By analysing the patterns of genetic variation among the samples, the researchers estimate that the VB variant first arose during the late 1980s and 1990s in the Netherlands. It spread more quickly than other HIV variants during the 2000s, but its spread has been declining since around 2010. The research team believe that the VB variant arose in spite of widespread treatment in the Netherlands, not because of it, since effective treatment can suppress transmission.
The individuals with the VB variant showed typical characteristics for people living with HIV in the Netherlands, including age, sex, and suspected mode of transmission. This indicates that the increased transmissibility of the VB variant is due to a property of the virus itself, rather than a characteristic of people with the virus.
https://www.eurekalert.org/news-releases/942283
INTRO: While frog and salamander declines worldwide have made scientists outspoken about the need to preserve amphibian genetic diversity, two University of California, Berkeley, biologists emphasize another important reason for conserving these animals: their poisons.
In a recent review of an endangered group — the colorful, yet poisonous, harlequin toads of Central and South America — Rebecca Tarvin and Kannon Pearson emphasize how little is known about the toxins these animals produce or sequester, or why they have them at all. Yet, of the 113 known species of harlequin toads, most are in decline, and a quarter may already be extinct.
Given that animal toxins have proved to be a useful source of pharmaceuticals — drugs already on the market derive from snake and snail venom, while toxins from the pufferfish, centipede and scorpion are in trials — inspiration for new drugs will be lost, along with the animals.
“In Central America, there's nine species of Atelopus, and seven of them have been assessed for toxin diversity and quantity,” said Tarvin, UC Berkeley assistant professor of integrative biology. “But the majority of the Atelopus species actually live in South America, where a minority of the studies have been done. There are entire countries, like Bolivia and Guyana, where not a single species has been assessed. We don't know of any reports of whether Indigenous people use them. We don't know if they're toxic or not. One of the takeaways from our paper is that by losing these animals, we're probably losing some chemical diversity, as well. They have some toxins that are found nowhere else in the world.” (MORE - details)
Discovery of new highly virulent and damaging HIV variant in the Netherlands
https://www.eurekalert.org/news-releases/941678
RELEASE: As the ongoing coronavirus pandemic has demonstrated, new mutations in viral genetic sequences can have significant impacts on the virus’s transmissibility and the damage it causes. For many years, there have been concerns that this could arise in the HIV-1 virus, which already affects 38 million people worldwide, and has caused 33 million deaths to date (www.unaids.org). This has now been confirmed with the discovery of a new, highly virulent HIV strain in the Netherlands, in a study led by researchers from the University of Oxford’s Big Data Institute. The results are published today in Science.
Individuals infected with the new “VB variant” (for virulent subtype B) showed significant differences before antiretroviral treatment compared with individuals infected with other HIV variants:
- Individuals with the VB variant had a viral load (the level of the virus in the blood) between 3.5 and 5.5 times higher.
- In addition, the rate of CD4 cell decline (the hallmark of immune system damage by HIV) occurred twice as fast in individuals with the VB variant, placing them at risk of developing AIDS much more rapidly.
- Individuals with the VB variant also showed an increased risk of transmitting the virus to others.
Further research to understand the mechanism that causes the VB variant to be more transmissible and damaging to the immune system could reveal new targets for next-generation antiretroviral drugs. The VB variant is characterized by many mutations spread throughout the genome, meaning that a single genetic cause cannot be identified at this stage.
Lead author Dr Chris Wymant, from the University of Oxford’s Big Data Institute and Nuffield Department of Medicine, said: ‘Before this study, the genetics of the HIV virus were known to be relevant for virulence, implying that the evolution of a new variant could change its impact on health. Discovery of the VB variant demonstrated this, providing a rare example of the risk posed by viral virulence evolution.’
Senior author Professor Christophe Fraser from the University of Oxford’s Big Data Institute and Nuffield Department of Medicine, added: ‘Our findings emphasise the importance of World Health Organization guidance that individuals at risk of acquiring HIV have access to regular testing to allow early diagnosis, followed by immediate treatment. This limits the amount of time HIV can damage an individual’s immune system and jeopardise their health. It also ensures that HIV is suppressed as quickly as possible, which prevents transmission to other individuals.’
The VB variant was first identified in 17 HIV positive individuals from the BEEHIVE project, an ongoing study which collects samples from across Europe and Uganda. Since 15 of these people came from the Netherlands, the researchers then analysed data from a cohort of over 6,700 HIV positive individuals in the Netherlands. This identified an additional 92 individuals with the variant, from all regions of the Netherlands, bringing the total to 109.
By analysing the patterns of genetic variation among the samples, the researchers estimate that the VB variant first arose during the late 1980s and 1990s in the Netherlands. It spread more quickly than other HIV variants during the 2000s, but its spread has been declining since around 2010. The research team believe that the VB variant arose in spite of widespread treatment in the Netherlands, not because of it, since effective treatment can suppress transmission.
The individuals with the VB variant showed typical characteristics for people living with HIV in the Netherlands, including age, sex, and suspected mode of transmission. This indicates that the increased transmissibility of the VB variant is due to a property of the virus itself, rather than a characteristic of people with the virus.