Jan 5, 2026 11:58 PM
(This post was last modified: Jan 6, 2026 12:06 AM by Yazata.)
https://www.psypost.org/restoring-a-spec...-syndrome/
"Changes to the structure of neurons in people with Down syndrome alter how they connect with each other. One major type of brain cell called astrocytes helps form connections between neurons. These star-shaped cells have many thin arms that extend into the spaces between neurons. They also secrete various proteins that are vital to forming the proper neural connections necessary for brain function.
Researchers have found that mouse models of several neurodevelopmental disorders, including Down syndrome, have altered levels of astrocyte proteins during development. My colleagues and I hypothesized that these changes might contribute to the changes in neural connections seen in Down syndrome. Could restoring the proper levels of some of these astrocyte proteins “rewire” the brain? ...
Among the top 10 proteins we identified was a molecule called pleiotrophin, or Ptn... We found that mice unable to produce Ptn had neurons with fewer branching arms, similar to what we saw in mice with Down syndrome. This correlation implies that proper Ptn levels are necessary to affect neuron branching during brain development.
Next, we wanted to know if delivering Ptn to astrocytes changes neural connections in mice with Down syndrome.
To answer that question, we packaged the gene for Ptn into a small virus with its replication genes removed. Called adeno-associated viruses, these tools allow researchers to deliver genetic material to specific targets in the body and are used for applications like gene therapy. We delivered the Ptn gene into astrocytes throughout the entire brain of adult mice with Down syndrome so we could evaluate its effects.
We focused on the visual cortex and the hippocampus, areas of the brain involved in vision and memory that are both critically affected in Down syndrome. After enhancing the ability of astrocytes to produce Ptn, we found that both regions recovered levels of neural branching density similar to those of mice without Down syndrome.
Finally, we wanted to see if we could actually restore electrical activity levels in the hippocampus by increasing astrocyte Ptn levels. Measuring electrical activity can indicate whether neurons are functioning properly. After delivering the Ptn gene to the astrocytes of mice with Down syndrome, we found the electrical activity of their hippocampus restored to levels no different from mice without Down syndrome."
Paper here:
https://www.cell.com/action/showPdf?pii=...%2901071-X
"Changes to the structure of neurons in people with Down syndrome alter how they connect with each other. One major type of brain cell called astrocytes helps form connections between neurons. These star-shaped cells have many thin arms that extend into the spaces between neurons. They also secrete various proteins that are vital to forming the proper neural connections necessary for brain function.
Researchers have found that mouse models of several neurodevelopmental disorders, including Down syndrome, have altered levels of astrocyte proteins during development. My colleagues and I hypothesized that these changes might contribute to the changes in neural connections seen in Down syndrome. Could restoring the proper levels of some of these astrocyte proteins “rewire” the brain? ...
Among the top 10 proteins we identified was a molecule called pleiotrophin, or Ptn... We found that mice unable to produce Ptn had neurons with fewer branching arms, similar to what we saw in mice with Down syndrome. This correlation implies that proper Ptn levels are necessary to affect neuron branching during brain development.
Next, we wanted to know if delivering Ptn to astrocytes changes neural connections in mice with Down syndrome.
To answer that question, we packaged the gene for Ptn into a small virus with its replication genes removed. Called adeno-associated viruses, these tools allow researchers to deliver genetic material to specific targets in the body and are used for applications like gene therapy. We delivered the Ptn gene into astrocytes throughout the entire brain of adult mice with Down syndrome so we could evaluate its effects.
We focused on the visual cortex and the hippocampus, areas of the brain involved in vision and memory that are both critically affected in Down syndrome. After enhancing the ability of astrocytes to produce Ptn, we found that both regions recovered levels of neural branching density similar to those of mice without Down syndrome.
Finally, we wanted to see if we could actually restore electrical activity levels in the hippocampus by increasing astrocyte Ptn levels. Measuring electrical activity can indicate whether neurons are functioning properly. After delivering the Ptn gene to the astrocytes of mice with Down syndrome, we found the electrical activity of their hippocampus restored to levels no different from mice without Down syndrome."
Paper here:
https://www.cell.com/action/showPdf?pii=...%2901071-X