Jul 26, 2025 12:26 AM
(This post was last modified: Jul 26, 2025 12:43 AM by C C.)
Parody Alcove: More science heresy about born women being physiologically different from psychological slash attire-based slash hormonal slash surgical women.
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Sex differences affect efficacy of opioid overdose treatment
https://www.eurekalert.org/news-releases/1092529
INTRO: Naloxone (also known as Narcan, the commonly used drug to treat narcotic overdoses) has greater binding to opioid receptors in women’s brains than in men’s brains, according to new research published in the July issue of The Journal of Nuclear Medicine. The first-in-human whole-body PET study suggests men and women may respond differently to opioid use disorder treatments and offers new insights to advance neuropharmacology.
Opioid misuse is a worldwide epidemic associated with high overdose and mortality rates. The μ-opioid receptor (MOR) is the target of opioid drugs including fentanyl and heroin, as well as well as naloxone, an opioid antagonist used to treat opioid use disorder. MORs are widely expressed in the central nervous system, peripheral organs, and immune system, making them especially useful for assessing functional changes in people with opioid use disorder.
“A better understanding of the interactions of opioid drugs with the MOR could help to elucidate the etiology, prevention, and treatment of opioid use disorder,” said Jacob Dubroff, MD, PhD, associate professor of radiology in the Division of Nuclear Medicine Imaging & Therapy at Perelman School of Medicine at the University of Pennsylvania in Philadelphia. “Using whole-body PET, we investigated MOR physiology in men and women before and after pretreatment with naloxone.” (MORE - details, no ads)
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Sex differences affect efficacy of opioid overdose treatment
https://www.eurekalert.org/news-releases/1092529
INTRO: Naloxone (also known as Narcan, the commonly used drug to treat narcotic overdoses) has greater binding to opioid receptors in women’s brains than in men’s brains, according to new research published in the July issue of The Journal of Nuclear Medicine. The first-in-human whole-body PET study suggests men and women may respond differently to opioid use disorder treatments and offers new insights to advance neuropharmacology.
Opioid misuse is a worldwide epidemic associated with high overdose and mortality rates. The μ-opioid receptor (MOR) is the target of opioid drugs including fentanyl and heroin, as well as well as naloxone, an opioid antagonist used to treat opioid use disorder. MORs are widely expressed in the central nervous system, peripheral organs, and immune system, making them especially useful for assessing functional changes in people with opioid use disorder.
“A better understanding of the interactions of opioid drugs with the MOR could help to elucidate the etiology, prevention, and treatment of opioid use disorder,” said Jacob Dubroff, MD, PhD, associate professor of radiology in the Division of Nuclear Medicine Imaging & Therapy at Perelman School of Medicine at the University of Pennsylvania in Philadelphia. “Using whole-body PET, we investigated MOR physiology in men and women before and after pretreatment with naloxone.” (MORE - details, no ads)