Dec 4, 2021 02:06 AM
(This post was last modified: Dec 4, 2021 02:34 AM by C C.)
Whether people inform themselves or remain ignorant is due to three factors
https://www.ucl.ac.uk/news/2021/dec/whet...ee-factors
RELEASE: People choose whether to seek or avoid information about their health, finances and personal traits based on how they think it will make them feel, how useful it is, and if it relates to things they think about often, finds a new study by UCL researchers.
Most people fall into one of three 'information-seeking types': those that mostly consider the impact of information on their feelings when deciding whether to get informed, those that mostly consider how useful information will be for making decisions, and those that mostly seek information about issues they think about often, according to the findings published in Nature Communications.
Co-lead author Professor Tali Sharot (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said: "Vast amounts of information are now available to individuals. This includes everything from information about your genetic make-up to information about social issues and the economy. We wanted to find out: how do people decide what they want to know? And why do some people actively seek out information, for example about COVID vaccines, financial inequality and climate change, and others don't?
"The information people decide to expose themselves to has important consequences for their health, finance and relationships. By better understanding why people choose to get informed, we could develop ways to convince people to educate themselves."
The researchers conducted five experiments with 543 research participants, to gauge what factors influence information-seeking.
In one of the experiments, participants were asked how much they would like to know about health information, such as whether they had an Alzheimer's risk gene or a gene conferring a strong immune system. In another experiment, they were asked whether they wanted to see financial information, such as exchange rates or what income percentile they fall into, and in another one, whether they would have liked to learn how their family and friends rated them on traits such as intelligence and laziness.
Later, participants were asked how useful they thought the information would be, how they expected it would make them feel, and how often they thought about each subject matter in question.
The researchers found that people choose to seek information based on these three factors: expected utility, emotional impact, and whether it was relevant to things they thought of often. This three-factor model best explained decisions to seek or avoid information compared to a range of other alternative models tested.
Some participants repeated the experiments a couple of times, months apart. The researchers found that most people prioritise one of the three motives (feelings, usefulness, frequency of thought) over the others, and their specific tendency remained relatively stable across time and domains, suggesting that what drives each person to seek information is 'trait-like'.
In two experiments, participants also filled out a questionnaire to gauge their general mental health. The researchers found that when people sought information about their own traits, participants who mostly wanted to know about traits they thought about often, reported better mental health.
Co-lead author, PhD student Christopher Kelly (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said: "By understanding people's motivations to seek information, policy makers may be able to increase the likelihood that people will engage with and benefit from vital information. For example, if policy makers highlight the potential usefulness of their message and the positive feelings that it may elicit, they may improve the effectiveness of their message.
"The research can also help policy makers decide whether information, for instance on food labels, needs to be disclosed, by describing how to fully assess the impact of information on welfare. At the moment policy-makers overlook the impact of information on people's emotions or ability to understand the world around them, and focus only on whether information can guide decisions." The study was funded by Wellcome.
Brain drain: Scientists explain why neurons consume so much fuel even when at rest
https://news.weill.cornell.edu/news/2021...en-at-rest
RELEASE: Pound for pound, the brain consumes vastly more energy than other organs, and, puzzlingly, it remains a fuel-guzzler even when its neurons are not firing signals called neurotransmitters to each other. Now researchers at Weill Cornell Medicine have found that the process of packaging neurotransmitters may be responsible for this energy drain.
In their study, reported Dec. 3 in Science Advances, they identified tiny capsules called synaptic vesicles as a major source of energy consumption in inactive neurons. Neurons use these vesicles as containers for their neurotransmitter molecules, which they fire from communications ports called synaptic terminals to signal to other neurons. Packing neurotransmitters into vesicles is a process that consumes chemical energy, and the researchers found that this process, energy-wise, is inherently leaky—so leaky that it continues to consume significant energy even when the vesicles are filled and synaptic terminals are inactive.
“These findings help us understand better why the human brain is so vulnerable to the interruption or weakening of its fuel supply,” said senior author Dr. Timothy Ryan, a professor of biochemistry and of biochemistry in anesthesiology at Weill Cornell Medicine.
The observation that the brain consumes a high amount of energy, even when relatively at rest, dates back several decades to studies of the brain’s fuel use in comatose and vegetative states. Those studies found that even in these profoundly inactive states, the brain’s consumption of glucose typically drops from normal by only about half—which still leaves the brain as a high energy consumer relative to other organs. The sources of that resting energy drain have never been fully understood.
Dr. Ryan and his laboratory have shown in recent years that neurons’ synaptic terminals, bud-like growths from which they fire neurotransmitters, are major consumers of energy when active, and are very sensitive to any disruption of their fuel supply. In the new study they examined fuel use in synaptic terminals when inactive, and found that it is still high.
This high resting fuel consumption, they discovered, is accounted for largely by the pool of vesicles at synaptic terminals. During synaptic inactivity, vesicles are fully loaded with thousands of neurotransmitters each, and are ready to launch these signal-carrying payloads across synapses to partner neurons.
Why would a synaptic vesicle consume energy even when fully loaded? The researchers discovered that there is essentially a leakage of energy from the vesicle membrane, a “proton efflux,” such that a special “proton pump” enzyme in the vesicle has to keep working, and consuming fuel as it does so, even when the vesicle is already full of neurotransmitter molecules.
The experiments pointed to proteins called transporters as the likely sources of this proton leakage. Transporters normally bring neurotransmitters into vesicles, changing shape to carry the neurotransmitter in, but allowing at the same time for a proton to escape—as they do so. Dr. Ryan speculates that the energy threshold for this transporter shape-shift was set low by evolution to enable faster neurotransmitter reloading during synaptic activity, and thus faster thinking and action.
“The downside of a faster loading capability would be that even random thermal fluctuations could trigger the transporter shape-shift, causing this continual energy drain even when no neurotransmitter is being loaded,” he said.
Although the leakage per vesicle would be tiny, there are at least hundreds of trillions of synaptic vesicles in the human brain, so the energy drain would really add up, Dr. Ryan said.
The finding is a significant advance in understanding the basic biology of the brain. In addition, the vulnerability of the brain to the disruption of its fuel supply is a major problem in neurology, and metabolic deficiencies have been noted in a host of common brain diseases including Alzheimer’s and Parkinson’s disease. This line of investigation ultimately could help solve important medical puzzles and suggest new treatments.
“If we had a way to safely lower this energy drain and thus slow brain metabolism, it could be very impactful clinically,” Dr. Ryan said.
https://www.ucl.ac.uk/news/2021/dec/whet...ee-factors
RELEASE: People choose whether to seek or avoid information about their health, finances and personal traits based on how they think it will make them feel, how useful it is, and if it relates to things they think about often, finds a new study by UCL researchers.
Most people fall into one of three 'information-seeking types': those that mostly consider the impact of information on their feelings when deciding whether to get informed, those that mostly consider how useful information will be for making decisions, and those that mostly seek information about issues they think about often, according to the findings published in Nature Communications.
Co-lead author Professor Tali Sharot (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said: "Vast amounts of information are now available to individuals. This includes everything from information about your genetic make-up to information about social issues and the economy. We wanted to find out: how do people decide what they want to know? And why do some people actively seek out information, for example about COVID vaccines, financial inequality and climate change, and others don't?
"The information people decide to expose themselves to has important consequences for their health, finance and relationships. By better understanding why people choose to get informed, we could develop ways to convince people to educate themselves."
The researchers conducted five experiments with 543 research participants, to gauge what factors influence information-seeking.
In one of the experiments, participants were asked how much they would like to know about health information, such as whether they had an Alzheimer's risk gene or a gene conferring a strong immune system. In another experiment, they were asked whether they wanted to see financial information, such as exchange rates or what income percentile they fall into, and in another one, whether they would have liked to learn how their family and friends rated them on traits such as intelligence and laziness.
Later, participants were asked how useful they thought the information would be, how they expected it would make them feel, and how often they thought about each subject matter in question.
The researchers found that people choose to seek information based on these three factors: expected utility, emotional impact, and whether it was relevant to things they thought of often. This three-factor model best explained decisions to seek or avoid information compared to a range of other alternative models tested.
Some participants repeated the experiments a couple of times, months apart. The researchers found that most people prioritise one of the three motives (feelings, usefulness, frequency of thought) over the others, and their specific tendency remained relatively stable across time and domains, suggesting that what drives each person to seek information is 'trait-like'.
In two experiments, participants also filled out a questionnaire to gauge their general mental health. The researchers found that when people sought information about their own traits, participants who mostly wanted to know about traits they thought about often, reported better mental health.
Co-lead author, PhD student Christopher Kelly (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said: "By understanding people's motivations to seek information, policy makers may be able to increase the likelihood that people will engage with and benefit from vital information. For example, if policy makers highlight the potential usefulness of their message and the positive feelings that it may elicit, they may improve the effectiveness of their message.
"The research can also help policy makers decide whether information, for instance on food labels, needs to be disclosed, by describing how to fully assess the impact of information on welfare. At the moment policy-makers overlook the impact of information on people's emotions or ability to understand the world around them, and focus only on whether information can guide decisions." The study was funded by Wellcome.
Brain drain: Scientists explain why neurons consume so much fuel even when at rest
https://news.weill.cornell.edu/news/2021...en-at-rest
RELEASE: Pound for pound, the brain consumes vastly more energy than other organs, and, puzzlingly, it remains a fuel-guzzler even when its neurons are not firing signals called neurotransmitters to each other. Now researchers at Weill Cornell Medicine have found that the process of packaging neurotransmitters may be responsible for this energy drain.
In their study, reported Dec. 3 in Science Advances, they identified tiny capsules called synaptic vesicles as a major source of energy consumption in inactive neurons. Neurons use these vesicles as containers for their neurotransmitter molecules, which they fire from communications ports called synaptic terminals to signal to other neurons. Packing neurotransmitters into vesicles is a process that consumes chemical energy, and the researchers found that this process, energy-wise, is inherently leaky—so leaky that it continues to consume significant energy even when the vesicles are filled and synaptic terminals are inactive.
“These findings help us understand better why the human brain is so vulnerable to the interruption or weakening of its fuel supply,” said senior author Dr. Timothy Ryan, a professor of biochemistry and of biochemistry in anesthesiology at Weill Cornell Medicine.
The observation that the brain consumes a high amount of energy, even when relatively at rest, dates back several decades to studies of the brain’s fuel use in comatose and vegetative states. Those studies found that even in these profoundly inactive states, the brain’s consumption of glucose typically drops from normal by only about half—which still leaves the brain as a high energy consumer relative to other organs. The sources of that resting energy drain have never been fully understood.
Dr. Ryan and his laboratory have shown in recent years that neurons’ synaptic terminals, bud-like growths from which they fire neurotransmitters, are major consumers of energy when active, and are very sensitive to any disruption of their fuel supply. In the new study they examined fuel use in synaptic terminals when inactive, and found that it is still high.
This high resting fuel consumption, they discovered, is accounted for largely by the pool of vesicles at synaptic terminals. During synaptic inactivity, vesicles are fully loaded with thousands of neurotransmitters each, and are ready to launch these signal-carrying payloads across synapses to partner neurons.
Why would a synaptic vesicle consume energy even when fully loaded? The researchers discovered that there is essentially a leakage of energy from the vesicle membrane, a “proton efflux,” such that a special “proton pump” enzyme in the vesicle has to keep working, and consuming fuel as it does so, even when the vesicle is already full of neurotransmitter molecules.
The experiments pointed to proteins called transporters as the likely sources of this proton leakage. Transporters normally bring neurotransmitters into vesicles, changing shape to carry the neurotransmitter in, but allowing at the same time for a proton to escape—as they do so. Dr. Ryan speculates that the energy threshold for this transporter shape-shift was set low by evolution to enable faster neurotransmitter reloading during synaptic activity, and thus faster thinking and action.
“The downside of a faster loading capability would be that even random thermal fluctuations could trigger the transporter shape-shift, causing this continual energy drain even when no neurotransmitter is being loaded,” he said.
Although the leakage per vesicle would be tiny, there are at least hundreds of trillions of synaptic vesicles in the human brain, so the energy drain would really add up, Dr. Ryan said.
The finding is a significant advance in understanding the basic biology of the brain. In addition, the vulnerability of the brain to the disruption of its fuel supply is a major problem in neurology, and metabolic deficiencies have been noted in a host of common brain diseases including Alzheimer’s and Parkinson’s disease. This line of investigation ultimately could help solve important medical puzzles and suggest new treatments.
“If we had a way to safely lower this energy drain and thus slow brain metabolism, it could be very impactful clinically,” Dr. Ryan said.
