Oct 15, 2021 08:32 PM
(This post was last modified: Oct 15, 2021 10:02 PM by C C.)
COVID-19 safety measures may have wiped out an entire flu lineage
https://www.iflscience.com/health-and-me...u-lineage/
INTRO: For most of us, the past two years have been spent wearing masks, washing our hands, and staying away from society to reduce the spread of COVID-19. According to a recent article published in the journal Nature Reviews Microbiology, these measures may have been doing twice as much good as we realized.
It’s an unintended – though certainly welcome – casualty of the world’s improved awareness of disease prevention: researchers at the University of Melbourne are suggesting that certain flu strains might now be extinct. The number and diversity of the surviving strains have been badly hit too, and even certain common cold viruses are feeling the heat.
“The SARS-CoV-2 pandemic has seen a notable global reduction in influenza cases of both influenza A and B viruses,” explain the authors. “In particular, the B/Yamagata lineage has not been isolated from April 2020 to August 2021, suggesting that this influenza lineage may have become extinct, which may provide opportunities for improving availability and effectiveness of influenza vaccines.”
There are four types of flu virus: A, B, C, and D – though as humans, we really only need to worry about A and B, since type C generally causes only mild illness and type D only infects cattle. Influenza A, fast-changing and diverse, is the type that causes pandemics. Influenza B clades – for example, B/Yamagata – tend to be confined to seasonal flu outbreaks.
Despite Influenza B types being slower to evolve, epidemiologists still get to see a few dozen or so new viruses develop per month. Since March 2020, however, there have been no B/Yamagata viruses detected at all. Even certain Influenza A viruses have been reduced, with the number of detections of H1N1 (aka swine flu) and H3N2 viruses dropping an order of magnitude year on year... (MORE)
Daily use of cannabidiol (‘CBD’) oil may be linked to lung cancer regression
https://casereports.bmj.com/content/14/10/e244195
RELEASE: It may be worth exploring further the use of cannabidiol (‘CBD’) oil as a potential lung cancer treatment, suggest doctors in BMJ Case Reports after dealing with a daily user whose lung tumour shrank without the aid of conventional treatment.
The body’s own endocannabinoids are involved in various processes, including nerve function, emotion, energy metabolism, pain and inflammation, sleep and immune function. Chemically similar to these endocannabinoids, cannabinoids can interact with signalling pathways in cells, including cancer cells. They have been studied for use as a primary cancer treatment, but the results have been inconsistent.
Lung cancer remains the second most common cancer in the UK. Despite treatment advances, survival rates remain low at around 15% five years after diagnosis. And average survival without treatment is around 7 months.
The report authors describe the case of a woman in her 80s, diagnosed with non-small cell lung cancer. She also had mild chronic obstructive pulmonary disease (COPD), osteoarthritis, and high blood pressure, for which she was taking various drugs. She was a smoker, getting through around a pack plus of cigarettes every week (68 packs/year).
Her tumour was 41 mm in size at diagnosis, with no evidence of local or further spread, so was suitable for conventional treatment of surgery, chemotherapy, and radiotherapy. But the woman refused treatment, so was placed under ‘watch and wait’ monitoring, which included regular CT scans every 3-6 months.
These showed that the tumour was progressively shrinking, reducing in size from 41 mm in June 2018 to 10 mm by February 2021, equal to an overall 76% reduction in maximum diameter, averaging 2.4% a month, say the report authors.
When contacted in 2019 to discuss her progress, the woman revealed that she had been taking CBD oil as an alternative self-treatment for her lung cancer since August 2018, shortly after her original diagnosis. She had done so on the advice of a relative, after witnessing her husband struggle with the side effects of radiotherapy. She said she consistently took 0.5 ml of the oil, usually three times a day, but sometimes twice.
The supplier had advised that the main active ingredients were Δ9-tetrahydrocannabinol (THC) at 19.5%, cannabidiol at around 20%, and tetrahydrocannabinolic acid (THCA) at around 24%. The supplier also advised that hot food or drinks should be avoided when taking the oil as she might otherwise feel stoned. The woman said she had reduced appetite since taking the oil but had no other obvious ‘side effects’. There were no other changes to her prescribed meds, diet, or lifestyle. And she continued to smoke throughout.
This is just one case report, with only one other similar case reported, caution the authors. And it’s not clear which of the CBD oil ingredients might have been helpful. “We are unable to confirm the full ingredients of the CBD oil that the patient was taking or to provide information on which of the ingredient(s) may be contributing to the observed tumour regression,” they point out.
And they emphasise: “Although there appears to be a relationship between the intake of CBD oil and the observed tumour regression, we are unable to conclusively confirm that the tumour regression is due to the patient taking CBD oil.”
Cannabis has a long ‘medicinal’ history in modern medicine, having been first introduced in 1842 for its analgesic, sedative, anti-inflammatory, antispasmodic and anticonvulsant effects. And it is widely believed that cannabinoids can help people with chronic pain, anxiety and sleep disorders; cannabinoids are also used in palliative care, the authors add. “More research is needed to identify the actual mechanism of action, administration pathways, safe dosages, its effects on different types of cancer and any potential adverse side effects when using cannabinoids,” they conclude.
https://www.iflscience.com/health-and-me...u-lineage/
INTRO: For most of us, the past two years have been spent wearing masks, washing our hands, and staying away from society to reduce the spread of COVID-19. According to a recent article published in the journal Nature Reviews Microbiology, these measures may have been doing twice as much good as we realized.
It’s an unintended – though certainly welcome – casualty of the world’s improved awareness of disease prevention: researchers at the University of Melbourne are suggesting that certain flu strains might now be extinct. The number and diversity of the surviving strains have been badly hit too, and even certain common cold viruses are feeling the heat.
“The SARS-CoV-2 pandemic has seen a notable global reduction in influenza cases of both influenza A and B viruses,” explain the authors. “In particular, the B/Yamagata lineage has not been isolated from April 2020 to August 2021, suggesting that this influenza lineage may have become extinct, which may provide opportunities for improving availability and effectiveness of influenza vaccines.”
There are four types of flu virus: A, B, C, and D – though as humans, we really only need to worry about A and B, since type C generally causes only mild illness and type D only infects cattle. Influenza A, fast-changing and diverse, is the type that causes pandemics. Influenza B clades – for example, B/Yamagata – tend to be confined to seasonal flu outbreaks.
Despite Influenza B types being slower to evolve, epidemiologists still get to see a few dozen or so new viruses develop per month. Since March 2020, however, there have been no B/Yamagata viruses detected at all. Even certain Influenza A viruses have been reduced, with the number of detections of H1N1 (aka swine flu) and H3N2 viruses dropping an order of magnitude year on year... (MORE)
Daily use of cannabidiol (‘CBD’) oil may be linked to lung cancer regression
https://casereports.bmj.com/content/14/10/e244195
RELEASE: It may be worth exploring further the use of cannabidiol (‘CBD’) oil as a potential lung cancer treatment, suggest doctors in BMJ Case Reports after dealing with a daily user whose lung tumour shrank without the aid of conventional treatment.
The body’s own endocannabinoids are involved in various processes, including nerve function, emotion, energy metabolism, pain and inflammation, sleep and immune function. Chemically similar to these endocannabinoids, cannabinoids can interact with signalling pathways in cells, including cancer cells. They have been studied for use as a primary cancer treatment, but the results have been inconsistent.
Lung cancer remains the second most common cancer in the UK. Despite treatment advances, survival rates remain low at around 15% five years after diagnosis. And average survival without treatment is around 7 months.
The report authors describe the case of a woman in her 80s, diagnosed with non-small cell lung cancer. She also had mild chronic obstructive pulmonary disease (COPD), osteoarthritis, and high blood pressure, for which she was taking various drugs. She was a smoker, getting through around a pack plus of cigarettes every week (68 packs/year).
Her tumour was 41 mm in size at diagnosis, with no evidence of local or further spread, so was suitable for conventional treatment of surgery, chemotherapy, and radiotherapy. But the woman refused treatment, so was placed under ‘watch and wait’ monitoring, which included regular CT scans every 3-6 months.
These showed that the tumour was progressively shrinking, reducing in size from 41 mm in June 2018 to 10 mm by February 2021, equal to an overall 76% reduction in maximum diameter, averaging 2.4% a month, say the report authors.
When contacted in 2019 to discuss her progress, the woman revealed that she had been taking CBD oil as an alternative self-treatment for her lung cancer since August 2018, shortly after her original diagnosis. She had done so on the advice of a relative, after witnessing her husband struggle with the side effects of radiotherapy. She said she consistently took 0.5 ml of the oil, usually three times a day, but sometimes twice.
The supplier had advised that the main active ingredients were Δ9-tetrahydrocannabinol (THC) at 19.5%, cannabidiol at around 20%, and tetrahydrocannabinolic acid (THCA) at around 24%. The supplier also advised that hot food or drinks should be avoided when taking the oil as she might otherwise feel stoned. The woman said she had reduced appetite since taking the oil but had no other obvious ‘side effects’. There were no other changes to her prescribed meds, diet, or lifestyle. And she continued to smoke throughout.
This is just one case report, with only one other similar case reported, caution the authors. And it’s not clear which of the CBD oil ingredients might have been helpful. “We are unable to confirm the full ingredients of the CBD oil that the patient was taking or to provide information on which of the ingredient(s) may be contributing to the observed tumour regression,” they point out.
And they emphasise: “Although there appears to be a relationship between the intake of CBD oil and the observed tumour regression, we are unable to conclusively confirm that the tumour regression is due to the patient taking CBD oil.”
Cannabis has a long ‘medicinal’ history in modern medicine, having been first introduced in 1842 for its analgesic, sedative, anti-inflammatory, antispasmodic and anticonvulsant effects. And it is widely believed that cannabinoids can help people with chronic pain, anxiety and sleep disorders; cannabinoids are also used in palliative care, the authors add. “More research is needed to identify the actual mechanism of action, administration pathways, safe dosages, its effects on different types of cancer and any potential adverse side effects when using cannabinoids,” they conclude.