Global spread of autoimmune disease blamed on junk food + The depression paradox

#1
C C Offline
The depression paradox: Treatments are better, but prevalence remains the same
https://bigthink.com/neuropsych/depressi...e-paradox/

KEY POINTS: Since the 1980s, treatments for major depressive disorder have improved and become more available. Despite these improvements, the prevalence of depression in recent decades has largely remained stagnant. A recent review found that depression treatments seem to be less effective than prior research suggests, and that research on depression treatments suffers from biases and other methodological problems. (MORE - details)


Global spread of autoimmune disease blamed on western diet (junk food)
https://www.theguardian.com/science/2022...stern-diet

EXCERPTS: More and more people around the world are suffering because their immune systems can no longer tell the difference between healthy cells and invading micro-organisms. Disease defences that once protected them are instead attacking their tissue and organs.

[...] “Numbers of autoimmune cases began to increase about 40 years ago in the west,” James Lee told the Observer. “However, we are now seeing some emerge in countries that never had such diseases before.

For example, the biggest recent increase in inflammatory bowel disease cases has been in the Middle East and east Asia. Before that they had hardly seen the disease.”

Autoimmune diseases range from type 1 diabetes to rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis. In each case, the immune system gets its wires crossed and turns on healthy tissue instead of infectious agents.

In the UK alone, at least 4 million people have developed such conditions [...] “Human genetics hasn’t altered over the past few decades,” said Lee, who was previously based at Cambridge University. “So something must be changing in the outside world in a way that is increasing our predisposition to autoimmune disease.”

This idea was backed by Carola Vinuesa, who was previously based at the Australian National University. She pointed to changes in diet that were occurring as more and more countries adopted western-style diets and people bought more fast food.

“Fast-food diets lack certain important ingredients, such as fibre, and evidence suggests this alteration affects a person’s microbiome – the collection of micro-organisms that we have in our gut and which play a key role in controlling various bodily functions,” Vinuesa said.

“These changes in our microbiomes are then triggering autoimmune diseases, of which more than 100 types have now been discovered.”

Both scientists stressed that individual susceptibilities were involved in contracting such illnesses, ailments that also include celiac disease as well as lupus, which triggers inflammation and swelling and can cause damage to various organs, including the heart... (MORE - missing details)
Reply
#2
Syne Offline
(Jan 12, 2022 05:34 PM)C C Wrote: The depression paradox: Treatments are better, but prevalence remains the same
https://bigthink.com/neuropsych/depressi...e-paradox/

KEY POINTS: Since the 1980s, treatments for major depressive disorder have improved and become more available. Despite these improvements, the prevalence of depression in recent decades has largely remained stagnant. A recent review found that depression treatments seem to be less effective than prior research suggests, and that research on depression treatments suffers from biases and other methodological problems. (MORE - details)

In general, the authors concluded that the efficacy of depression treatments in controlled trials is overestimated due to a variety of biases, including publication bias, outcome reporting bias, citation bias, and other methodological concerns.

This generally held true for acute depression treatments and longer-term maintenance treatments. (The authors noted that psychotherapy combined with medication tends to be most effective at treating acute depression and preventing relapse and recurrence, though the efficacy seems to be weaker than prior research reports.)

The review also found that depression treatments — even those tested under randomized, controlled trials — tend not to generalize well to real-world settings. “This compounds the observation that neither medication nor psychotherapy work as well as the (older) literature suggests,” they wrote. “Once transported into the real world, characterized by tougher patients and less adequate implementation, the already modest treatment effects for both medication and psychotherapy diminish even further.”


It's very hard to treat something that is effectively a dodge of the personal responsibility necessary to remedy it. Maybe a decreased belief in free will plays a roll in the decreased efficacy of treatment.
Reply


Possibly Related Threads…
Thread Author Replies Views Last Post
  Mystery disease in Canada stumps doctors Magical Realist 2 45 Jan 6, 2022 02:01 PM
Last Post: Secular Sanity
  Depression is more than low mood – it’s a change of consciousness C C 3 70 Jan 3, 2022 05:28 PM
Last Post: Syne
  Reciprocal relationship between depression & loneliness may decay within 6 years C C 0 10 Dec 9, 2021 12:33 AM
Last Post: C C
  Does depression exist? Nobody understands why therapy works. C C 19 213 Dec 3, 2021 11:14 PM
Last Post: Magical Realist
  Foods with saturated fat wrongly blamed for problems caused by refined carbohydrates C C 0 7 Nov 19, 2021 07:31 PM
Last Post: C C
  Brain-zapping, not drugs, helped depression + Artery size & stroke risk + Pickles C C 2 28 Oct 5, 2021 04:01 PM
Last Post: Zinjanthropos
  Man's penis stuck in bottle for months + Older women report depression more than men C C 2 54 Sep 29, 2021 02:51 PM
Last Post: Zinjanthropos
  As children fill ERs and ICUs, another COVID youth pandemic: depression & suicidality C C 1 23 Sep 18, 2021 09:00 PM
Last Post: Syne
  New insight into how omega-3 fatty acids or fish oil supps may reduce depression C C 12 366 Jun 21, 2021 04:41 AM
Last Post: Magical Realist
  Depression may literally be aging people’s bodies C C 0 27 Apr 9, 2021 12:32 AM
Last Post: C C



Users browsing this thread: 1 Guest(s)