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+--- Thread: Salmonella exposure a risk for colon cancer + Eating one fish: forever chemicals (/thread-13501.html)
Salmonella exposure a risk for colon cancer + Eating one fish: forever chemicals - C C - Jan 17, 2023
Eating one freshwater fish is like drinking a month’s worth of forever chemicals-laced water
https://www.zmescience.com/ecology/eating-one-freshwater-fish-is-like-drinking-a-months-worth-of-forever-chemicals/
INTRO: A new study has found that fish caught in streams, rivers, and lakes in the United States have dangerously high levels of perfluorooctane sulfonic acid (PFOS), a synthetic toxic substance in the ‘forever chemicals’ class that has been phased out by the federal government. Eating one fish in a year equals ingesting water with PFOS at 48 parts per trillion, or ppt, for one month — a dangerous threshold.
The chemical PFOS is part of a family of manufactured additives known as perfluoroalkyl and polyfluoroalkyl substances (PFAS), widely used since the 1950s to make consumer products nonstick and resistant to stains and grease damage. They are often called “forever chemicals” as they don’t break down easily in the environment.
These chemicals can stay in the soil and water for long periods of time, and can accumulate in the bodies of animals and humans. They are concerning because some studies have suggested that exposure to high levels of PFAS may be linked to certain health problems, such as cancer, thyroid issues, and immune system disorders. Since these chemicals can migrate into the air, dust, food, soil, and water, researchers are understandably concerned.
“People who consume freshwater fish, especially those who catch and eat fish regularly, are at risk of alarming levels of PFAS in their bodies,” David Andrews, one of the study’s lead authors, said in a statement. “Growing up, I went fishing every week and ate those fish. But now when I see fish, all I think about is PFAS contamination.” (MORE - details)
Salmonella exposure a risk for colon cancer
https://today.uic.edu/salmonella-exposure-a-risk-for-colon-cancer/
RELEASE: A new study published in the journal Cell Reports Medicine links exposure to salmonella bacteria to colon cancer risk.
The researchers, including a team led by Jun Sun from the University of Illinois Chicago, studied human colon cancer tissue samples and animal models and found that exposure to salmonella was linked with colon cancers that developed earlier and grew larger.
The study authors first looked at data from a Netherlands-based retrospective study of colon cancer patients that found tissue samples taken during routine colon cancer surgery with salmonella antibodies tended to be from people who had worse colon cancer outcomes.
Using salmonella strains isolated from these tissue samples, Sun and her U.S.-based team studied mice with colon cancer that had been exposed to the bacteria. They observed accelerated tumor growth and larger tumors in mice with salmonella exposure. They also saw that there was increased salmonella translocated to the tumors.
"During infection, salmonella hijacks essential host signaling pathways, and these molecular manipulations may cause oncogenic transformation. The current study tells us that more research is needed into the connection between salmonella exposure and colon cancer risk in the USA, and that simply by practicing safe food preparation, we can potentially help to protect ourselves," said Sun, UIC professor of medicine.
Sun's collaborators in the Netherlands also studied the bacteria in vitro. They combined human cancer cells and pre-cancer cells with the salmonella strain in the lab and measured any growth or changes in the tumor. They saw that even one infection caused transformation and that each salmonella infection exponentially increased the rate of cell transformation.
"The mouse and tissue culture experiments show that salmonella infection had a chronic effect to accelerate tumor growth," said Sun, who also is a member of the University of Illinois Cancer Center at UIC. "This evidence tells us that we need to look closer at salmonella exposure as an environmental risk factor for chronic diseases, such as colon cancer."
Leiden University Medical Center, the National Institute for Public Health and the Environment, and Utrecht University, all in the Netherlands, collaborated on this study.
In addition to Sun, co-authors of "Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth" include Daphne van Elsland, Janneke Duijster, Jilei Zhang, Virginie Stevenin, Yongguo Zhang, Lang Zha, Yinglin Xia, Eelco Franz, Lapo Mughini-Gras and Jacques Neefjes.
RE: Salmonella exposure a risk for colon cancer + Eating one fish: forever chemicals - Zinjanthropos - Jan 18, 2023
Always a NEW STUDY with a big MAY BE LINKED to this or that. Another favourite is STUDIES HAVE SUGGESTED and RESEARCHERS CONCERNED. It’s a bit of the boy who cried wolf. Do we get so accustomed to these health reports to the point of ignoring them altogether?
I guess I should be glad to be a sport fisherman only. I catch and release so am I better off than someone who eats what they catch? I still ended up with a cancer. Why aren’t saltwater fish on this report, is there something about salt that forever chemicals can’t handle? At least say it’s ok or mention they didn’t study that. Plants aren’t affected? Sounds fishy.