May 10, 2018 05:49 PM
http://www.bbc.com/news/health-44038756
"A potential new cure for baldness has been discovered using a drug originally intended to treat osteoporosis.
Researchers found the drug had a dramatic effect on hair follicles in the lab, stimulating them to grow.
It contains a compound which targets a protein that acts as a brake on hair growth and plays a role in baldness.
Project leader Dr Nathan Hawkshaw told the BBC a clinical trial would be needed to see if the treatment was effective and safe in people.
Only two drugs are currently available to treat balding (androgenetic alopecia):
minoxidil, for men and women
finasteride, for men only
Neither is available on the NHS and both have side-effects and are not always very effective, so patients often resort to hair transplantation surgery instead.
The research, published in PLOS Biology, was done in a lab, with samples containing scalp hair follicles from more than 40 male hair-transplant patients.
The researchers, from the University of Manchester, first latched onto an old immunosuppressive drug, cyclosporine A, used since the 1980s to prevent transplant organ rejection and reduce symptoms of autoimmune disease.
The scientists found that the drug reduced the activity of a protein called SFRP1, a key growth regulator that affects many tissues including hair follicles.
But because of its side effects, CsA was unsuitable as a baldness treatment.
The team went on to look for another agent that targeted SFRP1 and found that WAY-316606 was even better at suppressing the protein.
Dr Hawkshaw said the treatment could "make a real difference to people who suffer from hair loss".
What causes hair loss?
Hair loss is a daily occurrence and generally nothing to worry about. Some types are temporary and some are permanent.
You should see a doctor because of:
sudden hair loss
developing bald patches
losing hair in clumps
head itching and burning
worry about hair loss"
"A potential new cure for baldness has been discovered using a drug originally intended to treat osteoporosis.
Researchers found the drug had a dramatic effect on hair follicles in the lab, stimulating them to grow.
It contains a compound which targets a protein that acts as a brake on hair growth and plays a role in baldness.
Project leader Dr Nathan Hawkshaw told the BBC a clinical trial would be needed to see if the treatment was effective and safe in people.
Only two drugs are currently available to treat balding (androgenetic alopecia):
minoxidil, for men and women
finasteride, for men only
Neither is available on the NHS and both have side-effects and are not always very effective, so patients often resort to hair transplantation surgery instead.
The research, published in PLOS Biology, was done in a lab, with samples containing scalp hair follicles from more than 40 male hair-transplant patients.
The researchers, from the University of Manchester, first latched onto an old immunosuppressive drug, cyclosporine A, used since the 1980s to prevent transplant organ rejection and reduce symptoms of autoimmune disease.
The scientists found that the drug reduced the activity of a protein called SFRP1, a key growth regulator that affects many tissues including hair follicles.
But because of its side effects, CsA was unsuitable as a baldness treatment.
The team went on to look for another agent that targeted SFRP1 and found that WAY-316606 was even better at suppressing the protein.
Dr Hawkshaw said the treatment could "make a real difference to people who suffer from hair loss".
What causes hair loss?
Hair loss is a daily occurrence and generally nothing to worry about. Some types are temporary and some are permanent.
You should see a doctor because of:
sudden hair loss
developing bald patches
losing hair in clumps
head itching and burning
worry about hair loss"